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- W2082838104 abstract "In Brief Study Design. An in vitro human cadaveric biomechanical study. Objectives. To evaluate intervertebral rotation changes due to lumbar ProDisc-L compared with simulated fusion, using follower load and multidirectional testing. Summary of Background Data. Artificial discs, as opposed to the fusions, are thought to decrease the long-term accelerated degeneration at adjacent levels. A biomechanical assessment can be helpful, as the long-term clinical evaluation is impractical. Methods. Six fresh human cadaveric lumbar specimens (T12–S1) underwent multidirectional testing in flexion-extension, bilateral lateral bending, and bilateral torsion using the Hybrid test method. First, intact specimen total range of rotation (T12–S1) was determined. Second, using pure moments again, this range of rotation was achieved in each of the 5 constructs: A) ProDisc-L at L5–S1; B) fusion at L5–S1; C) ProDisc-L at L4–L5 and fusion at L5-S1; D) ProDisc-L at L4–L5 and L5–S1; and E) 2-level fusion at L4–L5 to L5–S1. Significant changes in the intervertebral rotations due to each construct were determined at the operated and nonoperated levels using repeated measures single factor ANOVA and Bonferroni statistical tests (P < 0.05). Adjacent-level effects (ALEs) were defined as the percentage changes in intervertebral rotations at the nonoperated levels due to the constructs. Results. One- and 2-level ProDisc-L constructs showed only small ALE in any of the 3 rotations. In contrast, 1- and 2-level fusions showed increased ALE in all 3 directions (average, 7.8% and 35.3%, respectively, for 1 and 2 levels). In the disc plus fusion combination (construct C), the ALEs were similar to the 1-level fusion alone. Conclusions. In general, ProDisc-L preserved physiologic motions at all spinal levels, while the fusion simulations resulted in significant ALE. One- and 2-level ProDisc-L were compared with the corresponding simulated fusions in flexion-extension, and bilateral lateral bending and torsion, using the Hybrid test method. ProDisc-L caused no significant increases in rotations at the nonoperated levels, while the simulated fusions did." @default.
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- W2082838104 date "2007-05-01" @default.
- W2082838104 modified "2023-09-30" @default.
- W2082838104 title "Multidirectional Testing of One- and Two-Level ProDisc-L Versus Simulated Fusions" @default.
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- W2082838104 doi "https://doi.org/10.1097/brs.0b013e318059af6f" @default.
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