FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2082847038> ?p ?o ?g. }

• W2082847038 endingPage "921" @default.
• W2082847038 startingPage "913" @default.
• W2082847038 abstract "OBJECTIVES: Potential celiac disease (CD) is defined by the presence of serum anti-tissue-transglutaminase (anti-TG2) antibodies and normal duodenal mucosa. The major clinical problem is the management of asymptomatic patients and how to predict the development of villous atrophy. This prospective longitudinal cohort study describes the natural history of potential CD up to 9 years and explores risk factors associated with the development of mucosal damage. METHODS: Two hundred and ten potential CD children were eligible for the study; 175/210 asymptomatic children were left on a gluten-containing diet. Antibodies and clinical symptoms were checked every 6 months, and a small bowel biopsy was taken every 2 years to evaluate histological, immunohistochemical, and anti-TG2 deposits. Patients were genotyped for HLA and a set of non-HLA CD-associated genes. RESULTS: Forty-three percent of patients showed persistently elevated anti-TG2 level, 20% became negative during follow-up, and 37% showed a fluctuant anti-TG2 course with transiently negative values. At 3 years of follow-up, 86% of cases remained potential; 73 and 67% still had normal duodenal architecture at 6 and 9 years, respectively. Male sex, slight mucosal inflammation at time 0, and a peculiar genetic profile delineate a cohort of individuals who were prone to develop mucosal damage during time. CONCLUSIONS: A sizeable proportion of asymptomatic potential celiac patients showed fluctuation or negativization of antibody production, and many of these, with persistently positive anti-TG2, did not develop mucosal damage after 9 years of follow-up. Celiac population is a multivariate aggregate of individuals with different genetic and phenotypic profiles. Caution is required before prescribing a gluten-free diet for life to asymptomatic individuals with potential CD." @default.
• W2082847038 created "2016-06-24" @default.
• W2082847038 creator A5016193284 @default.
• W2082847038 creator A5024403040 @default.
• W2082847038 creator A5029061517 @default.
• W2082847038 creator A5033692164 @default.
• W2082847038 creator A5037453067 @default.
• W2082847038 creator A5039858303 @default.
• W2082847038 creator A5049669094 @default.
• W2082847038 creator A5055751579 @default.
• W2082847038 creator A5081088896 @default.
• W2082847038 date "2014-06-01" @default.
• W2082847038 modified "2023-09-26" @default.
• W2082847038 title "Potential Celiac Children: 9-Year Follow-Up on a Gluten-Containing Diet" @default.
• W2082847038 cites W1631630133 @default.
• W2082847038 cites W1969319967 @default.
• W2082847038 cites W1970670432 @default.
• W2082847038 cites W1975705143 @default.
• W2082847038 cites W1978833652 @default.
• W2082847038 cites W1991473719 @default.
• W2082847038 cites W2001034231 @default.
• W2082847038 cites W2002448486 @default.
• W2082847038 cites W2010471813 @default.
• W2082847038 cites W2014832572 @default.
• W2082847038 cites W2031777928 @default.
• W2082847038 cites W2048821674 @default.
• W2082847038 cites W2050647893 @default.
• W2082847038 cites W2064463670 @default.
• W2082847038 cites W2065427932 @default.
• W2082847038 cites W2082657714 @default.
• W2082847038 cites W2083691642 @default.
• W2082847038 cites W2097282369 @default.
• W2082847038 cites W2100548379 @default.
• W2082847038 cites W2110056942 @default.
• W2082847038 cites W2113752878 @default.
• W2082847038 cites W2116579183 @default.
• W2082847038 cites W2123942305 @default.
• W2082847038 cites W2134138036 @default.
• W2082847038 cites W2134450123 @default.
• W2082847038 cites W2146641852 @default.
• W2082847038 cites W2156077720 @default.
• W2082847038 cites W2166003347 @default.
• W2082847038 cites W4210877064 @default.
• W2082847038 doi "https://doi.org/10.1038/ajg.2014.77" @default.
• W2082847038 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24777149" @default.
• W2082847038 hasPublicationYear "2014" @default.
• W2082847038 type Work @default.
• W2082847038 sameAs 2082847038 @default.
• W2082847038 citedByCount "87" @default.
• W2082847038 countsByYear W20828470382014 @default.
• W2082847038 countsByYear W20828470382015 @default.
• W2082847038 countsByYear W20828470382016 @default.
• W2082847038 countsByYear W20828470382017 @default.
• W2082847038 countsByYear W20828470382018 @default.
• W2082847038 countsByYear W20828470382019 @default.
• W2082847038 countsByYear W20828470382020 @default.
• W2082847038 countsByYear W20828470382021 @default.
• W2082847038 countsByYear W20828470382022 @default.
• W2082847038 countsByYear W20828470382023 @default.
• W2082847038 crossrefType "journal-article" @default.
• W2082847038 hasAuthorship W2082847038A5016193284 @default.
• W2082847038 hasAuthorship W2082847038A5024403040 @default.
• W2082847038 hasAuthorship W2082847038A5029061517 @default.
• W2082847038 hasAuthorship W2082847038A5033692164 @default.
• W2082847038 hasAuthorship W2082847038A5037453067 @default.
• W2082847038 hasAuthorship W2082847038A5039858303 @default.
• W2082847038 hasAuthorship W2082847038A5049669094 @default.
• W2082847038 hasAuthorship W2082847038A5055751579 @default.
• W2082847038 hasAuthorship W2082847038A5081088896 @default.
• W2082847038 hasConcept C126322002 @default.
• W2082847038 hasConcept C142724271 @default.
• W2082847038 hasConcept C159654299 @default.
• W2082847038 hasConcept C178498320 @default.
• W2082847038 hasConcept C181199279 @default.
• W2082847038 hasConcept C185592680 @default.
• W2082847038 hasConcept C188816634 @default.
• W2082847038 hasConcept C203014093 @default.
• W2082847038 hasConcept C2775934546 @default.
• W2082847038 hasConcept C2776336767 @default.
• W2082847038 hasConcept C2777910003 @default.
• W2082847038 hasConcept C2779134260 @default.
• W2082847038 hasConcept C2780349322 @default.
• W2082847038 hasConcept C2908647359 @default.
• W2082847038 hasConcept C2993432164 @default.
• W2082847038 hasConcept C55493867 @default.
• W2082847038 hasConcept C71924100 @default.
• W2082847038 hasConcept C72563966 @default.
• W2082847038 hasConcept C90924648 @default.
• W2082847038 hasConcept C99454951 @default.
• W2082847038 hasConceptScore W2082847038C126322002 @default.
• W2082847038 hasConceptScore W2082847038C142724271 @default.
• W2082847038 hasConceptScore W2082847038C159654299 @default.
• W2082847038 hasConceptScore W2082847038C178498320 @default.
• W2082847038 hasConceptScore W2082847038C181199279 @default.
• W2082847038 hasConceptScore W2082847038C185592680 @default.
• W2082847038 hasConceptScore W2082847038C188816634 @default.
• W2082847038 hasConceptScore W2082847038C203014093 @default.
• W2082847038 hasConceptScore W2082847038C2775934546 @default.

• next