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- W2082855305 abstract "Rat liver nuclei were used to study the metabolism of aflatoxin B1 (AFB1). Nuclei were found to metabolize AFB1 to aflatoxins M1(AFM1), Q1(AFQ1), and P1(AFP1); the formation of AFP1 was relatively negligible. AFM1 was preferentially formed when rats were pretreated with 3-methylcholanthrene (MC), whereas phenobarbital (PB) pretreatment enhanced the formation of both AFM1 and AFQ1. PB pretreatment also resulted in increased binding of AFB1 metabolites to DNA and to other macromolecules in the nucleus. Following PB and MC pretreatment, induction specificities of the nuclear metabolism of AFB1 were similar to those of the microsomal metabolism." @default.
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- W2082855305 date "1977-11-01" @default.
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- W2082855305 title "metabolism of aflatoxin B1 by rat liver nuclei" @default.
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- W2082855305 doi "https://doi.org/10.1016/0024-3205(77)90205-3" @default.
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