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• W2082868445 startingPage "461" @default.
• W2082868445 abstract "Introduction: Metabotropic glutamate receptor 4 (mGlu4) is a group III GPCR and has been demonstrated to play a major role in a number of therapeutic areas within the CNS. As the orthosteric site of all glutamate receptors is highly conserved, modulating mGlu4 via allosteric modulation has emerged as a very attractive mode-of-action and has been validated preclinically in a number of animal models for Parkinson's disease, anxiety, pain, and neuroinflammation. Areas covered: In this review, the patent literature for mGlu4-positive allosteric modulators over the past 4 years will be provided. Patents from all companies are discussed and an overview of the chemical matter and relevant biological properties will be given. Expert opinion: Although there has yet to be an mGlu4-positive allosteric modulator progressed into clinical trials, there is a wealth of preclinical data from the primary literature that shows the promise of this emerging target. A number of academic and industry laboratories have recently published exciting patent data covering a multitude of chemical matter. Positive allosteric modulation of mGlu4 remains one of the more attractive non-dopaminergic therapies for Parkinson's disease, as well as emerging data for other indications such as pain, neuroinflammation, schizophrenia and diabetes, which could potentially make mGlu4 a significant therapeutic target going forward." @default.
• W2082868445 created "2016-06-24" @default.
• W2082868445 creator A5033139685 @default.
• W2082868445 creator A5060483072 @default.
• W2082868445 date "2012-04-16" @default.
• W2082868445 modified "2023-09-27" @default.
• W2082868445 title "Metabotropic glutamate receptor 4 (mGlu₄)-positive allosteric modulators for the treatment of Parkinson's disease: historical perspective and review of the patent literature" @default.
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• W2082868445 doi "https://doi.org/10.1517/13543776.2012.679437" @default.
• W2082868445 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22506633" @default.
• W2082868445 hasPublicationYear "2012" @default.
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