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- W2082883204 abstract "Transformation of physiologically important 3-hydroxy-steroids by the DHEA-induced 7α-hydroxylase of F. moniliforme was investigated. Whereas DHEA was almost totally 7α-hydroxylated, PREG, EPIA and ESTR were only partially converted into their 7α-hydroxylated derivatives because hydroxylation at other undetermined positions as well as reduction of ketone at C17 or C20 into hydroxyl also occurred. Cholesterol was not transformed by the enzyme. Kinetic parameters of the 7α-hydroxylation for these substrates were determined and confirmed that DHEA was the best substrate of the 7α-hydroxylase. Inhibition studies of DHEA 7α-hydroxylation by the other 3-hydroxy-steroids were also carried out and proved that DHEA, PREG, EPIA and ESTR shared the same active site of the enzyme. Induction effects of these steroids were compared, and DHEA appeared to be the best inducer of the 7α-hydroxylase of F. moniliforme." @default.
- W2082883204 created "2016-06-24" @default.
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- W2082883204 date "1999-03-01" @default.
- W2082883204 modified "2023-10-14" @default.
- W2082883204 title "Transformation of 3-hydroxy-steroids by Fusarium moniliforme 7α-hydroxylase" @default.
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- W2082883204 doi "https://doi.org/10.1016/s0960-0760(99)00035-7" @default.
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