Matches in SemOpenAlex for { <https://semopenalex.org/work/W2082887072> ?p ?o ?g. }
- W2082887072 abstract "Human adenoviruses (HAdVs) are highly contagious pathogens causing acute respiratory disease (ARD), among other illnesses. Of the ARD genotypes, HAdV-7 presents with more severe morbidity and higher mortality than the others. We report the isolation and identification of a genome type HAdV-7d (DG01_2011) from a recent outbreak in Southern China. Genome sequencing, phylogenetic analysis and restriction endonuclease analysis (REA) comparisons with past pathogens indicate HAdV-7d has re-emerged in Southern China after an absence of twenty-one years. Recombination analysis reveals this genome differs from the 1950s-era prototype and vaccine strains by a lateral gene transfer, substituting the coding region for the L1 52/55 kDa DNA packaging protein from HAdV-16. DG01_2011 descends from both a strain circulating in Southwestern China (2010) and a strain from Shaanxi causing a fatality and outbreak (Northwestern China; 2009). Due to the higher morbidity and mortality rates associated with HAdV-7, the surveillance, identification and characterization of these strains in population-dense China by REA and/or whole genome sequencing are strongly indicated. With these accurate identifications of specific HAdV types and an epidemiological database of regional HAdV pathogens, along with the HAdV genome stability noted across time and space, the development, availability and deployment of appropriate vaccines are needed." @default.
- W2082887072 created "2016-06-24" @default.
- W2082887072 creator A5000989447 @default.
- W2082887072 creator A5001515212 @default.
- W2082887072 creator A5003376712 @default.
- W2082887072 creator A5005179685 @default.
- W2082887072 creator A5011591486 @default.
- W2082887072 creator A5026915472 @default.
- W2082887072 creator A5029140232 @default.
- W2082887072 creator A5032057325 @default.
- W2082887072 creator A5033357672 @default.
- W2082887072 creator A5042786682 @default.
- W2082887072 creator A5056792888 @default.
- W2082887072 creator A5057143504 @default.
- W2082887072 creator A5057894585 @default.
- W2082887072 creator A5061256445 @default.
- W2082887072 creator A5076901800 @default.
- W2082887072 creator A5089149074 @default.
- W2082887072 creator A5090845983 @default.
- W2082887072 date "2014-12-08" @default.
- W2082887072 modified "2023-10-01" @default.
- W2082887072 title "Re-emergent Human Adenovirus Genome Type 7d Caused an Acute Respiratory Disease Outbreak in Southern China After a Twenty-one Year Absence" @default.
- W2082887072 cites W1479801479 @default.
- W2082887072 cites W1484823371 @default.
- W2082887072 cites W1492028108 @default.
- W2082887072 cites W1595018629 @default.
- W2082887072 cites W1704448806 @default.
- W2082887072 cites W1840624602 @default.
- W2082887072 cites W1843289124 @default.
- W2082887072 cites W1907806866 @default.
- W2082887072 cites W1973895065 @default.
- W2082887072 cites W1974547861 @default.
- W2082887072 cites W1976868395 @default.
- W2082887072 cites W1987892487 @default.
- W2082887072 cites W1988673221 @default.
- W2082887072 cites W1997039649 @default.
- W2082887072 cites W2000800050 @default.
- W2082887072 cites W2004490430 @default.
- W2082887072 cites W2005231588 @default.
- W2082887072 cites W2006205150 @default.
- W2082887072 cites W2007092117 @default.
- W2082887072 cites W2007933676 @default.
- W2082887072 cites W2010740724 @default.
- W2082887072 cites W2011030841 @default.
- W2082887072 cites W2023159788 @default.
- W2082887072 cites W2025344688 @default.
- W2082887072 cites W2029096834 @default.
- W2082887072 cites W2030682536 @default.
- W2082887072 cites W2031016277 @default.
- W2082887072 cites W2032052837 @default.
- W2082887072 cites W2032611797 @default.
- W2082887072 cites W2033425416 @default.
- W2082887072 cites W2036035780 @default.
- W2082887072 cites W2038140742 @default.
- W2082887072 cites W2040943940 @default.
- W2082887072 cites W2045624781 @default.
- W2082887072 cites W2051164613 @default.
- W2082887072 cites W2056381325 @default.
- W2082887072 cites W2061803918 @default.
- W2082887072 cites W2064071745 @default.
- W2082887072 cites W2072746405 @default.
- W2082887072 cites W2074819081 @default.
- W2082887072 cites W2095113978 @default.
- W2082887072 cites W2097699811 @default.
- W2082887072 cites W2105236815 @default.
- W2082887072 cites W2109515000 @default.
- W2082887072 cites W2110255171 @default.
- W2082887072 cites W2110462501 @default.
- W2082887072 cites W2118993491 @default.
- W2082887072 cites W2123745267 @default.
- W2082887072 cites W2132632499 @default.
- W2082887072 cites W2134330422 @default.
- W2082887072 cites W2135102207 @default.
- W2082887072 cites W2136875106 @default.
- W2082887072 cites W2138505075 @default.
- W2082887072 cites W2144648859 @default.
- W2082887072 cites W2163400707 @default.
- W2082887072 cites W2163772805 @default.
- W2082887072 cites W2165084682 @default.
- W2082887072 cites W2169743800 @default.
- W2082887072 cites W2249729856 @default.
- W2082887072 cites W2292198715 @default.
- W2082887072 cites W2316528098 @default.
- W2082887072 cites W2321393228 @default.
- W2082887072 cites W2363217548 @default.
- W2082887072 cites W2401246102 @default.
- W2082887072 cites W2411141322 @default.
- W2082887072 cites W2412923126 @default.
- W2082887072 cites W4249665736 @default.
- W2082887072 cites W4323053900 @default.
- W2082887072 doi "https://doi.org/10.1038/srep07365" @default.
- W2082887072 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4258649" @default.
- W2082887072 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25482188" @default.
- W2082887072 hasPublicationYear "2014" @default.
- W2082887072 type Work @default.
- W2082887072 sameAs 2082887072 @default.
- W2082887072 citedByCount "68" @default.
- W2082887072 countsByYear W20828870722015 @default.
- W2082887072 countsByYear W20828870722016 @default.
- W2082887072 countsByYear W20828870722017 @default.