FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2082896913> ?p ?o ?g. }

• W2082896913 endingPage "1772" @default.
• W2082896913 startingPage "1765" @default.
• W2082896913 abstract "The selenoprotein thioredoxin reductase is a key enzyme in selenium metabolism, reducing selenium compounds and thereby providing selenide to synthesis of all selenoproteins. We evaluated the importance of active TrxR1 in selenium-induced cytotoxicity using transfected TrxR1 over-expressing stable Human Embryo Kidney (HEK-293) cells and modulation of activity by pretreatment with low concentration of selenite. Treatment with sodium selenite induced cytotoxity in a dose-dependent manner in both TrxR1 over-expressing and control cells. However, TrxR1 over-expressing cells, which were preincubated for 72h with 0.1 microM selenite, were significantly more resistant to selenite cytotoxicity than control cells. To demonstrate the early effects of selenite on behaviour of HEK-293 cells, we also investigated the influence of this compound on cell motility. We observed inhibition of cell motility by 50 microM selenite immediately after administration. Moreover, TrxR1 over-expressing cells preincubated with a low concentration of selenite were more resistant to the inhibitory effect of 50 microM selenite than those not preincubated. It was also observed that the TrxR over-expressing cells showed higher TrxR1 activity than control cells and the preincubation of over-expressing cells with 0.1 microM selenite induced further significant increase in the activity of TrxR1. On the other hand, we demonstrated that TrxR1 over-expressing cells showed decreased glutathione peroxidase activity compared to control cells. These data strongly suggest that TrxR1 may be a crucial enzyme responsible for cell resistance against selenium cytotoxicity." @default.
• W2082896913 created "2016-06-24" @default.
• W2082896913 creator A5013158098 @default.
• W2082896913 creator A5018200566 @default.
• W2082896913 creator A5036830331 @default.
• W2082896913 creator A5039779401 @default.
• W2082896913 creator A5046930689 @default.
• W2082896913 creator A5049320367 @default.
• W2082896913 creator A5065411783 @default.
• W2082896913 creator A5065437701 @default.
• W2082896913 creator A5068286660 @default.
• W2082896913 creator A5071887651 @default.
• W2082896913 creator A5077367417 @default.
• W2082896913 date "2005-06-01" @default.
• W2082896913 modified "2023-10-16" @default.
• W2082896913 title "The role of thioredoxin reductase activity in selenium-induced cytotoxicity" @default.
• W2082896913 cites W1514004257 @default.
• W2082896913 cites W1574486032 @default.
• W2082896913 cites W1668286863 @default.
• W2082896913 cites W1975980695 @default.
• W2082896913 cites W1982820068 @default.
• W2082896913 cites W1983397667 @default.
• W2082896913 cites W2018729412 @default.
• W2082896913 cites W2020958483 @default.
• W2082896913 cites W2035655379 @default.
• W2082896913 cites W2038199668 @default.
• W2082896913 cites W2038344815 @default.
• W2082896913 cites W2040902678 @default.
• W2082896913 cites W2042567737 @default.
• W2082896913 cites W2055172401 @default.
• W2082896913 cites W2065020384 @default.
• W2082896913 cites W2071497993 @default.
• W2082896913 cites W2076289444 @default.
• W2082896913 cites W2084004698 @default.
• W2082896913 cites W2092317255 @default.
• W2082896913 cites W2118400439 @default.
• W2082896913 cites W2118498917 @default.
• W2082896913 cites W2118928636 @default.
• W2082896913 cites W2125628477 @default.
• W2082896913 cites W2149585271 @default.
• W2082896913 cites W4295115868 @default.
• W2082896913 doi "https://doi.org/10.1016/j.bcp.2005.02.023" @default.
• W2082896913 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15935149" @default.
• W2082896913 hasPublicationYear "2005" @default.
• W2082896913 type Work @default.
• W2082896913 sameAs 2082896913 @default.
• W2082896913 citedByCount "46" @default.
• W2082896913 countsByYear W20828969132012 @default.
• W2082896913 countsByYear W20828969132013 @default.
• W2082896913 countsByYear W20828969132014 @default.
• W2082896913 countsByYear W20828969132015 @default.
• W2082896913 countsByYear W20828969132019 @default.
• W2082896913 countsByYear W20828969132020 @default.
• W2082896913 countsByYear W20828969132021 @default.
• W2082896913 countsByYear W20828969132022 @default.
• W2082896913 countsByYear W20828969132023 @default.
• W2082896913 crossrefType "journal-article" @default.
• W2082896913 hasAuthorship W2082896913A5013158098 @default.
• W2082896913 hasAuthorship W2082896913A5018200566 @default.
• W2082896913 hasAuthorship W2082896913A5036830331 @default.
• W2082896913 hasAuthorship W2082896913A5039779401 @default.
• W2082896913 hasAuthorship W2082896913A5046930689 @default.
• W2082896913 hasAuthorship W2082896913A5049320367 @default.
• W2082896913 hasAuthorship W2082896913A5065411783 @default.
• W2082896913 hasAuthorship W2082896913A5065437701 @default.
• W2082896913 hasAuthorship W2082896913A5068286660 @default.
• W2082896913 hasAuthorship W2082896913A5071887651 @default.
• W2082896913 hasAuthorship W2082896913A5077367417 @default.
• W2082896913 hasConcept C104317684 @default.
• W2082896913 hasConcept C109316439 @default.
• W2082896913 hasConcept C153911025 @default.
• W2082896913 hasConcept C174510640 @default.
• W2082896913 hasConcept C178790620 @default.
• W2082896913 hasConcept C181199279 @default.
• W2082896913 hasConcept C185592680 @default.
• W2082896913 hasConcept C202751555 @default.
• W2082896913 hasConcept C2776841403 @default.
• W2082896913 hasConcept C2777737464 @default.
• W2082896913 hasConcept C2778760513 @default.
• W2082896913 hasConcept C3623737 @default.
• W2082896913 hasConcept C538909803 @default.
• W2082896913 hasConcept C54009773 @default.
• W2082896913 hasConcept C54355233 @default.
• W2082896913 hasConcept C553756173 @default.
• W2082896913 hasConcept C55493867 @default.
• W2082896913 hasConcept C81885089 @default.
• W2082896913 hasConcept C86803240 @default.
• W2082896913 hasConceptScore W2082896913C104317684 @default.
• W2082896913 hasConceptScore W2082896913C109316439 @default.
• W2082896913 hasConceptScore W2082896913C153911025 @default.
• W2082896913 hasConceptScore W2082896913C174510640 @default.
• W2082896913 hasConceptScore W2082896913C178790620 @default.
• W2082896913 hasConceptScore W2082896913C181199279 @default.
• W2082896913 hasConceptScore W2082896913C185592680 @default.
• W2082896913 hasConceptScore W2082896913C202751555 @default.
• W2082896913 hasConceptScore W2082896913C2776841403 @default.
• W2082896913 hasConceptScore W2082896913C2777737464 @default.
• W2082896913 hasConceptScore W2082896913C2778760513 @default.

• next