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- W2082898686 abstract "The topical application of hydrocortisone is of benefit in some dermatologie disorders, especially pruritus ani. An early manifestation of its value is a reduction in the pruritus. The mechanism of this antipruritic effect has not been explained and a number of recent articles (1, 2, 3, 4, 5) do not even discuss the possible mechanisms by which this might be accomplished. Rothman (6) believes that the systemic administration of corticosteroids reduces itching only if the underlying disease is itself influenced by the drug, and he believes f that the effects of topical hydrocortisone in reducing itching are secondary to the antiinflammatory action of the drug. Cormia (7) refers to the effect of ACTH on some patients with ano-genital pruritus. In one patient the itch threshold (elicited by histamine) on non-pruritic skin was unaffected by ACTH. He suggests that ACTH may affect only the pruritic area or it might affect cortical reception of itch stimuli." @default.
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- W2082898686 date "1957-08-01" @default.
- W2082898686 modified "2023-09-29" @default.
- W2082898686 title "Studies on Itching" @default.
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- W2082898686 doi "https://doi.org/10.1038/jid.1957.75" @default.
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