Matches in SemOpenAlex for { <https://semopenalex.org/work/W2082904312> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W2082904312 abstract "The rapid progression of chronic hepatitis C (CHC) in HIV-infected patients is now the most important cause of morbidity, mortality and hospital admissions. In order to avoid this evolution, the treatment of CHC is a major challenge in these patients.The aim of this study is to evaluate the safety and efficacy of treatment of CHC in HIV-infected patients with subcutaneous IFN (3 MU 3 times a week) plus Ribavirin (RBV) administered per 200 mg dosage depending on their body weight, for 24 weeks for genotype 2 or 3 and 48 weeks for genotype 1 or 4. All the patients have a CD4 count over 150 cells/microl and HIV viral load < 50,000 copies/ml, with or without antiretroviral treatment. We defined sustained response as RNA-VHC below level of detection 24 weeks after the end of treatment.We included 28 patients in the study, with median age of 36.6 y.o. 82% of the patients were on antiretroviral treatment, with AZT in 60% of them. Genotype distribution was HCV-1 in 50%, HCV-3 in 35.7%, HCV-4 in 10.7% and HCV-2 in 3%. Liver biopsy was performed in all the patients. Adverse events leading to treatment discontinuation occurred in 5 patients (17.8%). The overall sustained response rate in the intent-to-treat analysis was 25.8% (50% for genotype 3 and 14% for genotype 1).This therapy provides cure in a rate significantly lower than that seen in HCV-monoinfected individuals, with a similar safety. The modern formulations of IFN (pegylated) will provide new expectatives in this group of patients." @default.
- W2082904312 created "2016-06-24" @default.
- W2082904312 creator A5053351049 @default.
- W2082904312 creator A5068217739 @default.
- W2082904312 date "2004-08-01" @default.
- W2082904312 modified "2023-10-18" @default.
- W2082904312 title "Tratamiento con interferón y ribavirina de la hepatitis crónica por virus C en pacientes con infección por VIH" @default.
- W2082904312 doi "https://doi.org/10.4321/s0212-71992004000800002" @default.
- W2082904312 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15373718" @default.
- W2082904312 hasPublicationYear "2004" @default.
- W2082904312 type Work @default.
- W2082904312 sameAs 2082904312 @default.
- W2082904312 citedByCount "2" @default.
- W2082904312 countsByYear W20829043122016 @default.
- W2082904312 crossrefType "journal-article" @default.
- W2082904312 hasAuthorship W2082904312A5053351049 @default.
- W2082904312 hasAuthorship W2082904312A5068217739 @default.
- W2082904312 hasBestOaLocation W20829043121 @default.
- W2082904312 hasConcept C104317684 @default.
- W2082904312 hasConcept C126322002 @default.
- W2082904312 hasConcept C135763542 @default.
- W2082904312 hasConcept C142462285 @default.
- W2082904312 hasConcept C185592680 @default.
- W2082904312 hasConcept C197934379 @default.
- W2082904312 hasConcept C203014093 @default.
- W2082904312 hasConcept C2522874641 @default.
- W2082904312 hasConcept C2776408679 @default.
- W2082904312 hasConcept C2776455275 @default.
- W2082904312 hasConcept C2778715236 @default.
- W2082904312 hasConcept C2780040827 @default.
- W2082904312 hasConcept C3013748606 @default.
- W2082904312 hasConcept C55493867 @default.
- W2082904312 hasConcept C71924100 @default.
- W2082904312 hasConcept C90924648 @default.
- W2082904312 hasConceptScore W2082904312C104317684 @default.
- W2082904312 hasConceptScore W2082904312C126322002 @default.
- W2082904312 hasConceptScore W2082904312C135763542 @default.
- W2082904312 hasConceptScore W2082904312C142462285 @default.
- W2082904312 hasConceptScore W2082904312C185592680 @default.
- W2082904312 hasConceptScore W2082904312C197934379 @default.
- W2082904312 hasConceptScore W2082904312C203014093 @default.
- W2082904312 hasConceptScore W2082904312C2522874641 @default.
- W2082904312 hasConceptScore W2082904312C2776408679 @default.
- W2082904312 hasConceptScore W2082904312C2776455275 @default.
- W2082904312 hasConceptScore W2082904312C2778715236 @default.
- W2082904312 hasConceptScore W2082904312C2780040827 @default.
- W2082904312 hasConceptScore W2082904312C3013748606 @default.
- W2082904312 hasConceptScore W2082904312C55493867 @default.
- W2082904312 hasConceptScore W2082904312C71924100 @default.
- W2082904312 hasConceptScore W2082904312C90924648 @default.
- W2082904312 hasIssue "8" @default.
- W2082904312 hasLocation W20829043121 @default.
- W2082904312 hasLocation W20829043122 @default.
- W2082904312 hasOpenAccess W2082904312 @default.
- W2082904312 hasPrimaryLocation W20829043121 @default.
- W2082904312 hasRelatedWork W1598582479 @default.
- W2082904312 hasRelatedWork W2021325302 @default.
- W2082904312 hasRelatedWork W2040326692 @default.
- W2082904312 hasRelatedWork W2129522191 @default.
- W2082904312 hasRelatedWork W2136349201 @default.
- W2082904312 hasRelatedWork W2352920887 @default.
- W2082904312 hasRelatedWork W2413741471 @default.
- W2082904312 hasRelatedWork W2417030504 @default.
- W2082904312 hasRelatedWork W2737479186 @default.
- W2082904312 hasRelatedWork W2755121454 @default.
- W2082904312 hasVolume "21" @default.
- W2082904312 isParatext "false" @default.
- W2082904312 isRetracted "false" @default.
- W2082904312 magId "2082904312" @default.
- W2082904312 workType "article" @default.