FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2082904905> ?p ?o ?g. }

• W2082904905 endingPage "86" @default.
• W2082904905 startingPage "81" @default.
• W2082904905 abstract "Macrophages play a critical role in innate immune response to protect the host from pathogenic microorganisms. Inflammatory response is regulated by negative feedback mechanisms to prevent detrimental effects. The SOCS family of proteins is key component of the negative feedback loop that regulates the intensity, duration and quality of cytokine signaling, whereas miR-155 is a key regulator of Toll-like receptor (TLR) signaling that targets SOCS1 in activated macrophages to block the negative feedback loop. Recently we showed that 1,25-dihydroxyvitamin D (1,25(OH)2D3) modulates innate immune response by targeting the miR-155-SOCS1 axis. We found that Vdr deletion leads to hyper inflammatory response in mice and macrophage cultures when challenged with lipopolysaccharide (LPS), due to miR-155 overproduction to excessively suppress SOCS1. Using mice with bic/miR-155 deletion we confirmed that 1,25(OH)2D3 suppresses inflammation and stimulates SOCS1 by down-regulating miR-155. Mechanistically 1,25(OH)2D3 down-regulates bic transcription by blocking NF-κB activation, which is mediated by a κB cis-DNA element identified within the first intron of the bic gene. At the molecular level, we demonstrated that VDR inhibits NF-κB activation by directly interacting with IKKβ protein. Our studies identified a novel mechanism whereby VDR signaling attenuates TLR-mediated inflammation by enhancing the negative feedback regulation. This article is part of a Special Issue entitled '16th Vitamin D Workshop'." @default.
• W2082904905 created "2016-06-24" @default.
• W2082904905 creator A5012129149 @default.
• W2082904905 creator A5041339585 @default.
• W2082904905 creator A5067038494 @default.
• W2082904905 creator A5089137150 @default.
• W2082904905 date "2014-10-01" @default.
• W2082904905 modified "2023-10-16" @default.
• W2082904905 title "MicroRNA-mediated mechanism of vitamin D regulation of innate immune response" @default.
• W2082904905 cites W144423133 @default.
• W2082904905 cites W1510351486 @default.
• W2082904905 cites W1543525745 @default.
• W2082904905 cites W1967007963 @default.
• W2082904905 cites W1968008181 @default.
• W2082904905 cites W1970516100 @default.
• W2082904905 cites W1972181361 @default.
• W2082904905 cites W1974102799 @default.
• W2082904905 cites W1976077502 @default.
• W2082904905 cites W1984382389 @default.
• W2082904905 cites W1993197717 @default.
• W2082904905 cites W1998060649 @default.
• W2082904905 cites W2001962405 @default.
• W2082904905 cites W2004465286 @default.
• W2082904905 cites W2014869583 @default.
• W2082904905 cites W2017481656 @default.
• W2082904905 cites W2017851530 @default.
• W2082904905 cites W2018938924 @default.
• W2082904905 cites W2024716296 @default.
• W2082904905 cites W2030120875 @default.
• W2082904905 cites W2031746740 @default.
• W2082904905 cites W2034835460 @default.
• W2082904905 cites W2036586400 @default.
• W2082904905 cites W2038177382 @default.
• W2082904905 cites W2039615146 @default.
• W2082904905 cites W2044153851 @default.
• W2082904905 cites W2048178760 @default.
• W2082904905 cites W2049772720 @default.
• W2082904905 cites W2051287129 @default.
• W2082904905 cites W2054630945 @default.
• W2082904905 cites W2055878807 @default.
• W2082904905 cites W2059691278 @default.
• W2082904905 cites W2067647130 @default.
• W2082904905 cites W2072076620 @default.
• W2082904905 cites W2073414064 @default.
• W2082904905 cites W2074150439 @default.
• W2082904905 cites W2079294041 @default.
• W2082904905 cites W2093442991 @default.
• W2082904905 cites W2094464340 @default.
• W2082904905 cites W2099126377 @default.
• W2082904905 cites W2106449126 @default.
• W2082904905 cites W2119282152 @default.
• W2082904905 cites W2124580054 @default.
• W2082904905 cites W2124957695 @default.
• W2082904905 cites W2133226725 @default.
• W2082904905 cites W2138153315 @default.
• W2082904905 cites W2143300196 @default.
• W2082904905 cites W2160098916 @default.
• W2082904905 cites W2164360357 @default.
• W2082904905 cites W2170281485 @default.
• W2082904905 cites W4238545515 @default.
• W2082904905 doi "https://doi.org/10.1016/j.jsbmb.2013.09.014" @default.
• W2082904905 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3976893" @default.
• W2082904905 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24103701" @default.
• W2082904905 hasPublicationYear "2014" @default.
• W2082904905 type Work @default.
• W2082904905 sameAs 2082904905 @default.
• W2082904905 citedByCount "38" @default.
• W2082904905 countsByYear W20829049052014 @default.
• W2082904905 countsByYear W20829049052015 @default.
• W2082904905 countsByYear W20829049052016 @default.
• W2082904905 countsByYear W20829049052017 @default.
• W2082904905 countsByYear W20829049052018 @default.
• W2082904905 countsByYear W20829049052019 @default.
• W2082904905 countsByYear W20829049052020 @default.
• W2082904905 countsByYear W20829049052021 @default.
• W2082904905 countsByYear W20829049052022 @default.
• W2082904905 countsByYear W20829049052023 @default.
• W2082904905 crossrefType "journal-article" @default.
• W2082904905 hasAuthorship W2082904905A5012129149 @default.
• W2082904905 hasAuthorship W2082904905A5041339585 @default.
• W2082904905 hasAuthorship W2082904905A5067038494 @default.
• W2082904905 hasAuthorship W2082904905A5089137150 @default.
• W2082904905 hasBestOaLocation W20829049052 @default.
• W2082904905 hasConcept C104317684 @default.
• W2082904905 hasConcept C136449434 @default.
• W2082904905 hasConcept C14077384 @default.
• W2082904905 hasConcept C145059251 @default.
• W2082904905 hasConcept C170493617 @default.
• W2082904905 hasConcept C179185449 @default.
• W2082904905 hasConcept C179639408 @default.
• W2082904905 hasConcept C203014093 @default.
• W2082904905 hasConcept C2776914184 @default.
• W2082904905 hasConcept C2778690821 @default.
• W2082904905 hasConcept C2778754761 @default.
• W2082904905 hasConcept C54355233 @default.
• W2082904905 hasConcept C62478195 @default.
• W2082904905 hasConcept C86339819 @default.
• W2082904905 hasConcept C86803240 @default.

• next