FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2082906650> ?p ?o ?g. }

• W2082906650 endingPage "521" @default.
• W2082906650 startingPage "515" @default.
• W2082906650 abstract "To assess the efficacy of leukotriene synthesis inhibitors, alone and in combination with a nonsteroidal antiinflammatory drug, as potential treatments for rheumatoid arthritis (RA), using the mouse air pouch model and the collagen-induced arthritis (CIA) model.Two selective leukotriene synthesis inhibitors, Bay x 1005 and Bay y 1015, were compared with zileuton in terms of their ability to decrease exudate volume, cell infiltration, and leukotriene B4 (LTB4) production in response to zymosan injection in the mouse air pouch model. The mouse CIA model was used to assess the effect of leukotriene synthesis inhibitors in a model of chronic inflammation. Bay y 1015 and Bay x 1005, and the cyclooxygenase inhibitor naproxen, were evaluated individually and in combination, for their antiarthritic potency in the mouse CIA model.The results indicate that neither zileuton, Bay x 1005, nor Bay y 1015 inhibited exudate production. All 3 compounds decreased LTB4 levels in be air pouch, with Bay y 1015 being the most effective. Cell infiltration was significantly decreased with Bay x 1005, but the degree of this decrease did not appear to correlate with LTB4 levels. No inhibition of arthritis was observed with any compound administered alone. In contrast, a significant inhibition of CIA was observed in animals that received both naproxen and either Bay y 1015 or Bay x 1005.Inhibitors of both cyclooxygenase and leukotriene synthesis in combination may be a more effective treatment of RA than either class of inhibitors alone." @default.
• W2082906650 created "2016-06-24" @default.
• W2082906650 creator A5009359618 @default.
• W2082906650 creator A5074638279 @default.
• W2082906650 date "1996-03-01" @default.
• W2082906650 modified "2023-09-30" @default.
• W2082906650 title "The effect of leukotriene synthesis inhibitors in models of acute and chronic inflammation" @default.
• W2082906650 cites W1964249507 @default.
• W2082906650 cites W1968830866 @default.
• W2082906650 cites W1973029255 @default.
• W2082906650 cites W1975832104 @default.
• W2082906650 cites W1976912963 @default.
• W2082906650 cites W1981592867 @default.
• W2082906650 cites W1993725936 @default.
• W2082906650 cites W1999783546 @default.
• W2082906650 cites W2000802993 @default.
• W2082906650 cites W2000983477 @default.
• W2082906650 cites W2004740907 @default.
• W2082906650 cites W2015279384 @default.
• W2082906650 cites W2023213942 @default.
• W2082906650 cites W2038937666 @default.
• W2082906650 cites W2044871104 @default.
• W2082906650 cites W2051010723 @default.
• W2082906650 cites W2052327108 @default.
• W2082906650 cites W2056870877 @default.
• W2082906650 cites W2057473693 @default.
• W2082906650 cites W2062916785 @default.
• W2082906650 cites W2067239929 @default.
• W2082906650 cites W2067595559 @default.
• W2082906650 cites W2070401832 @default.
• W2082906650 cites W2089616538 @default.
• W2082906650 cites W2094483802 @default.
• W2082906650 cites W2098532478 @default.
• W2082906650 cites W2108139718 @default.
• W2082906650 cites W2331507609 @default.
• W2082906650 doi "https://doi.org/10.1002/art.1780390320" @default.
• W2082906650 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8607901" @default.
• W2082906650 hasPublicationYear "1996" @default.
• W2082906650 type Work @default.
• W2082906650 sameAs 2082906650 @default.
• W2082906650 citedByCount "47" @default.
• W2082906650 countsByYear W20829066502012 @default.
• W2082906650 countsByYear W20829066502013 @default.
• W2082906650 countsByYear W20829066502015 @default.
• W2082906650 countsByYear W20829066502016 @default.
• W2082906650 countsByYear W20829066502018 @default.
• W2082906650 countsByYear W20829066502022 @default.
• W2082906650 crossrefType "journal-article" @default.
• W2082906650 hasAuthorship W2082906650A5009359618 @default.
• W2082906650 hasAuthorship W2082906650A5074638279 @default.
• W2082906650 hasConcept C115880899 @default.
• W2082906650 hasConcept C127413603 @default.
• W2082906650 hasConcept C142724271 @default.
• W2082906650 hasConcept C147176958 @default.
• W2082906650 hasConcept C181199279 @default.
• W2082906650 hasConcept C185592680 @default.
• W2082906650 hasConcept C203014093 @default.
• W2082906650 hasConcept C204787440 @default.
• W2082906650 hasConcept C2776042228 @default.
• W2082906650 hasConcept C2776452501 @default.
• W2082906650 hasConcept C2776685179 @default.
• W2082906650 hasConcept C2776914184 @default.
• W2082906650 hasConcept C2777077863 @default.
• W2082906650 hasConcept C2777575956 @default.
• W2082906650 hasConcept C2778078955 @default.
• W2082906650 hasConcept C2778115740 @default.
• W2082906650 hasConcept C2779543280 @default.
• W2082906650 hasConcept C2779689624 @default.
• W2082906650 hasConcept C2781370401 @default.
• W2082906650 hasConcept C55493867 @default.
• W2082906650 hasConcept C71924100 @default.
• W2082906650 hasConcept C90342290 @default.
• W2082906650 hasConcept C98274493 @default.
• W2082906650 hasConceptScore W2082906650C115880899 @default.
• W2082906650 hasConceptScore W2082906650C127413603 @default.
• W2082906650 hasConceptScore W2082906650C142724271 @default.
• W2082906650 hasConceptScore W2082906650C147176958 @default.
• W2082906650 hasConceptScore W2082906650C181199279 @default.
• W2082906650 hasConceptScore W2082906650C185592680 @default.
• W2082906650 hasConceptScore W2082906650C203014093 @default.
• W2082906650 hasConceptScore W2082906650C204787440 @default.
• W2082906650 hasConceptScore W2082906650C2776042228 @default.
• W2082906650 hasConceptScore W2082906650C2776452501 @default.
• W2082906650 hasConceptScore W2082906650C2776685179 @default.
• W2082906650 hasConceptScore W2082906650C2776914184 @default.
• W2082906650 hasConceptScore W2082906650C2777077863 @default.
• W2082906650 hasConceptScore W2082906650C2777575956 @default.
• W2082906650 hasConceptScore W2082906650C2778078955 @default.
• W2082906650 hasConceptScore W2082906650C2778115740 @default.
• W2082906650 hasConceptScore W2082906650C2779543280 @default.
• W2082906650 hasConceptScore W2082906650C2779689624 @default.
• W2082906650 hasConceptScore W2082906650C2781370401 @default.
• W2082906650 hasConceptScore W2082906650C55493867 @default.
• W2082906650 hasConceptScore W2082906650C71924100 @default.
• W2082906650 hasConceptScore W2082906650C90342290 @default.
• W2082906650 hasConceptScore W2082906650C98274493 @default.
• W2082906650 hasIssue "3" @default.
• W2082906650 hasLocation W20829066501 @default.

• next