Matches in SemOpenAlex for { <https://semopenalex.org/work/W2082912152> ?p ?o ?g. }
- W2082912152 endingPage "R107" @default.
- W2082912152 startingPage "R101" @default.
- W2082912152 abstract "Prolactin-releasing peptide (PrRP) reduces food intake and body weight and modifies body temperature when administered centrally in rats, suggesting a role in energy homeostasis. However, the mediators of PrRP's actions are unknown. The present study, therefore, first examined the possible involvement of the anorectic neuropeptides corticotropin-releasing hormone (CRH) and the melanocortins (e.g., α-melanocyte-stimulating hormone) in PrRP's effects on food intake and core body temperature and, second, determined if PrRP affects energy expenditure by measuring oxygen consumption (V̇o 2 ). Intracerebroventricular injection of PrRP (4 nmol) to 24-h-fasted male Sprague-Dawley rats decreased food intake and modified body temperature. Blockade of central CRH receptors by intracerebroventricular coadministration of the CRH receptor antagonist astressin (20 μg) reversed the PrRP-induced reduction in feeding. However, astressin's effect on PrRP-induced changes in body temperature was complicated because the antagonist itself caused a slight rise in body temperature. In contrast, intracerebroventricular coadministration of the melanocortin receptor-3/4 antagonist SHU-9119 (0.1 nmol) had no effect on any of PrRP's actions. Finally, intracerebroventricular injection of PrRP (4 nmol) caused a significantly greater V̇o 2 over a 3-h test period compared with vehicle-treated rats. These results show that the anorectic actions of PrRP are mediated by central CRH receptors but not by melanocortin receptors-3/4 and that PrRP can modify V̇o 2 ." @default.
- W2082912152 created "2016-06-24" @default.
- W2082912152 creator A5020884489 @default.
- W2082912152 creator A5022545503 @default.
- W2082912152 creator A5073934003 @default.
- W2082912152 creator A5075724588 @default.
- W2082912152 date "2004-01-01" @default.
- W2082912152 modified "2023-10-16" @default.
- W2082912152 title "Anorectic actions of prolactin-releasing peptide are mediated by corticotropin-releasing hormone receptors" @default.
- W2082912152 cites W1531005638 @default.
- W2082912152 cites W1719679764 @default.
- W2082912152 cites W1851182293 @default.
- W2082912152 cites W1860710445 @default.
- W2082912152 cites W1963797237 @default.
- W2082912152 cites W1964889875 @default.
- W2082912152 cites W1967755293 @default.
- W2082912152 cites W1973987443 @default.
- W2082912152 cites W1976092788 @default.
- W2082912152 cites W1978900877 @default.
- W2082912152 cites W1983119517 @default.
- W2082912152 cites W1989918919 @default.
- W2082912152 cites W1993003470 @default.
- W2082912152 cites W2000529226 @default.
- W2082912152 cites W2004834430 @default.
- W2082912152 cites W2007528115 @default.
- W2082912152 cites W2007772279 @default.
- W2082912152 cites W2012574167 @default.
- W2082912152 cites W2016638042 @default.
- W2082912152 cites W2019164797 @default.
- W2082912152 cites W2021507909 @default.
- W2082912152 cites W2025626906 @default.
- W2082912152 cites W2026169142 @default.
- W2082912152 cites W2028710649 @default.
- W2082912152 cites W2030418024 @default.
- W2082912152 cites W2032865136 @default.
- W2082912152 cites W2034800901 @default.
- W2082912152 cites W2037561124 @default.
- W2082912152 cites W2037940390 @default.
- W2082912152 cites W2038406912 @default.
- W2082912152 cites W2038872854 @default.
- W2082912152 cites W2041736210 @default.
- W2082912152 cites W2045678388 @default.
- W2082912152 cites W2045707187 @default.
- W2082912152 cites W2059239672 @default.
- W2082912152 cites W2065389660 @default.
- W2082912152 cites W2068737035 @default.
- W2082912152 cites W2088252221 @default.
- W2082912152 cites W2093362450 @default.
- W2082912152 cites W2094861690 @default.
- W2082912152 cites W2095566802 @default.
- W2082912152 cites W2095620291 @default.
- W2082912152 cites W2095646540 @default.
- W2082912152 cites W2096200312 @default.
- W2082912152 cites W2105105112 @default.
- W2082912152 cites W2106041840 @default.
- W2082912152 cites W2110607315 @default.
- W2082912152 cites W2116775721 @default.
- W2082912152 cites W2119682245 @default.
- W2082912152 cites W2127231901 @default.
- W2082912152 cites W2127514796 @default.
- W2082912152 cites W2133635537 @default.
- W2082912152 cites W2163893850 @default.
- W2082912152 cites W2170015886 @default.
- W2082912152 cites W2170136606 @default.
- W2082912152 cites W2171010063 @default.
- W2082912152 cites W2334462456 @default.
- W2082912152 doi "https://doi.org/10.1152/ajpregu.00402.2003" @default.
- W2082912152 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14512273" @default.
- W2082912152 hasPublicationYear "2004" @default.
- W2082912152 type Work @default.
- W2082912152 sameAs 2082912152 @default.
- W2082912152 citedByCount "62" @default.
- W2082912152 countsByYear W20829121522012 @default.
- W2082912152 countsByYear W20829121522013 @default.
- W2082912152 countsByYear W20829121522014 @default.
- W2082912152 countsByYear W20829121522015 @default.
- W2082912152 countsByYear W20829121522016 @default.
- W2082912152 countsByYear W20829121522018 @default.
- W2082912152 countsByYear W20829121522019 @default.
- W2082912152 countsByYear W20829121522020 @default.
- W2082912152 countsByYear W20829121522021 @default.
- W2082912152 countsByYear W20829121522022 @default.
- W2082912152 crossrefType "journal-article" @default.
- W2082912152 hasAuthorship W2082912152A5020884489 @default.
- W2082912152 hasAuthorship W2082912152A5022545503 @default.
- W2082912152 hasAuthorship W2082912152A5073934003 @default.
- W2082912152 hasAuthorship W2082912152A5075724588 @default.
- W2082912152 hasConcept C118303440 @default.
- W2082912152 hasConcept C126322002 @default.
- W2082912152 hasConcept C134018914 @default.
- W2082912152 hasConcept C170493617 @default.
- W2082912152 hasConcept C185592680 @default.
- W2082912152 hasConcept C2491326 @default.
- W2082912152 hasConcept C2776885963 @default.
- W2082912152 hasConcept C2777369949 @default.
- W2082912152 hasConcept C2779993316 @default.
- W2082912152 hasConcept C3018685816 @default.
- W2082912152 hasConcept C71315377 @default.