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• W2082920258 abstract "Since the mid‐1990s, there have been tremendous advances in our understanding of the roles that lipid‐modifying enzymes play in various intracellular membrane trafficking events. Phospholipases represent the largest group of lipid‐modifying enzymes and accordingly display a wide range of functions. The largest class of phospholipases are the phospholipase A( 2 ) (PLA 2 ) enzymes, and these have been most extensively studied for their roles in the generation lipid signaling molecules, e.g. arachidonic acid. In recent years, however, cytoplasmic PLA 2 enzymes have also become increasingly associated with various intracellular trafficking events, such as the formation of membrane tubules from the Golgi complex and endosomes, and membrane fusion events in the secretory and endocytic pathways. Moreover, the ability of cytoplasmic PLA 2 enzymes to directly affect the structure and function of membranes by altering membrane curvature suggests novel functional roles for these enzymes. This review will focus on the role of cytoplasmic PLA 2 enzymes in intracellular membrane trafficking and the mechanisms by which they influence membrane structure and function ." @default.
• W2082920258 created "2016-06-24" @default.
• W2082920258 creator A5038684364 @default.
• W2082920258 creator A5038879680 @default.
• W2082920258 creator A5087673492 @default.
• W2082920258 date "2003-04-01" @default.
• W2082920258 modified "2023-10-15" @default.
• W2082920258 title "Phospholipase A₂(PLA₂) Enzymes in Membrane Trafficking: Mediators of Membrane Shape and Function" @default.
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• W2082920258 doi "https://doi.org/10.1034/j.1600-0854.2003.00078.x" @default.
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