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• W2082930718 abstract "Disabled-2 (Dab2) is an endocytic adaptor protein involved in clathrin-mediated endocytosis and cargo trafficking. Since its expression is lost in several cancer types, Dab2 has been suggested to be a tumor suppressor. In vitro studies indicate that Dab2 establishes epithelial cell polarity and organization by directing endocytic trafficking of membrane glycoproteins. Dab2 also modulates cellular signaling pathways by mediating the endocytosis and recycling of surface receptors and associated signaling components. Previously, two independent gene knockout studies have been reported, with some discrepancies in the observed embryonic phenotypes. To further clarify the in vivo roles of Dab2 in development and physiology, we designed a new floxed allele to delete dab2 gene.The constitutive dab2 deleted embryos showed a spectrum in the degree of endoderm disorganization in E5.5 and no mutant embryos persisted at E9.5. However, the mice were grossly normal when dab2 deletion was restricted to the embryo proper and the gene was retained in extraembryonic tissues using Meox2-Cre and Sox2-Cre. Adult Dab2-deficient mice had a small but statistically significant increase in serum cholesterol levels.The study of the new dab2 mutant allele in embryos and embryoid bodies confirms a role for Dab2 in extraembryonic endoderm development and epithelial organization. Experimental results with embryoid bodies suggest that additional endocytic adaptors such as Arh and Numb could partially compensate for Dab2 loss. Conditional deletion indicates that Dab2 is dispensable for organ development, when the vast majority of the embryonic cells are dab2 null. However, Dab2 has a physiological role in the endocytosis of lipoproteins and cholesterol metabolism." @default.
• W2082930718 created "2016-06-24" @default.
• W2082930718 creator A5008482982 @default.
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• W2082930718 creator A5079001775 @default.
• W2082930718 creator A5082403692 @default.
• W2082930718 date "2013-10-29" @default.
• W2082930718 modified "2023-10-17" @default.
• W2082930718 title "Differential requirement for Dab2 in the development of embryonic and extra-embryonic tissues" @default.
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• W2082930718 doi "https://doi.org/10.1186/1471-213x-13-39" @default.
• W2082930718 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3924344" @default.
• W2082930718 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24168030" @default.
• W2082930718 hasPublicationYear "2013" @default.
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