FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2082933786> ?p ?o ?g. }

• W2082933786 endingPage "139" @default.
• W2082933786 startingPage "129" @default.
• W2082933786 abstract "Many antigens recognized by tumor-reactive cytotoxic CD8+ T cells are self-antigens. Tyrosinase-related protein 2 (TRP-2) is a melanogenic enzyme expressed by both melanocytes and melanomas that is reported to be a candidate melanoma rejection antigen. To study the role of self-reactive CD8+ T cells in tumor immunity and autoimmunity, we generated mice that bear a T-cell receptor transgene (TCR Tg) specific for the TRP-2(180-188) epitope. TRP-2 TCR Tg mice did not spontaneously develop depigmentation despite systemic expression of TRP-2 in the skin. Peripheral T cells from these TCR Tg mice exhibited a naive phenotype and proliferated in response to TRP-2 in vitro. In addition, transfer of in vitro-activated Tg T cells reduced B16 pulmonary tumor burden, but not subcutaneous tumors. We next sought to determine the in vivo responses of the Tg T cells to endogenous and tumor-derived TRP-2. Adoptive transfer of naive TCR Tg T cells into wild-type C57BL/6 mice, in combination with a TRP-2–pulsed dendritic cell vaccine, induced proliferation of the Tg T cells and resulted in migration of the Tg T cells into a subcutaneous B16 melanoma tumor. Although these tumor-infiltrating Tg T cells remained reactive against TRP-2, they did not reduce growth of the primary subcutaneous tumor; similarly, these in vivo-primed effector cells had no significant effect on the growth of pulmonary nodules. These data demonstrate that despite in vivo priming, tumor-infiltrating T cells may fail to reduce tumor burden. Determining the basis for the inability of the tumor microenvironment to sustain effective antitumor responses will be critical for designing newer, more potent antitumor immunotherapies." @default.
• W2082933786 created "2016-06-24" @default.
• W2082933786 creator A5002886067 @default.
• W2082933786 creator A5027994557 @default.
• W2082933786 creator A5032771596 @default.
• W2082933786 creator A5056971062 @default.
• W2082933786 creator A5071714593 @default.
• W2082933786 date "2009-02-01" @default.
• W2082933786 modified "2023-09-27" @default.
• W2082933786 title "Melanoma Progression Despite Infiltration by In Vivo-primed TRP-2–specific T Cells" @default.
• W2082933786 cites W1571861420 @default.
• W2082933786 cites W1623460711 @default.
• W2082933786 cites W1748278816 @default.
• W2082933786 cites W1967577151 @default.
• W2082933786 cites W1967684158 @default.
• W2082933786 cites W1998522604 @default.
• W2082933786 cites W1999273079 @default.
• W2082933786 cites W2001640241 @default.
• W2082933786 cites W2008494452 @default.
• W2082933786 cites W2047547740 @default.
• W2082933786 cites W2056964537 @default.
• W2082933786 cites W2069426612 @default.
• W2082933786 cites W2078760290 @default.
• W2082933786 cites W2085213267 @default.
• W2082933786 cites W2087986967 @default.
• W2082933786 cites W2090177390 @default.
• W2082933786 cites W2097009175 @default.
• W2082933786 cites W2098772563 @default.
• W2082933786 cites W2103018035 @default.
• W2082933786 cites W2105017308 @default.
• W2082933786 cites W2110932366 @default.
• W2082933786 cites W2111217091 @default.
• W2082933786 cites W2114657480 @default.
• W2082933786 cites W2120003042 @default.
• W2082933786 cites W2121535726 @default.
• W2082933786 cites W2121885873 @default.
• W2082933786 cites W2122957377 @default.
• W2082933786 cites W2129092670 @default.
• W2082933786 cites W2130185552 @default.
• W2082933786 cites W2140341414 @default.
• W2082933786 cites W2146641471 @default.
• W2082933786 cites W2153746213 @default.
• W2082933786 cites W2159573388 @default.
• W2082933786 cites W2161371315 @default.
• W2082933786 cites W4239133705 @default.
• W2082933786 doi "https://doi.org/10.1097/cji.0b013e31819144d7" @default.
• W2082933786 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2648128" @default.
• W2082933786 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19238011" @default.
• W2082933786 hasPublicationYear "2009" @default.
• W2082933786 type Work @default.
• W2082933786 sameAs 2082933786 @default.
• W2082933786 citedByCount "32" @default.
• W2082933786 countsByYear W20829337862012 @default.
• W2082933786 countsByYear W20829337862013 @default.
• W2082933786 countsByYear W20829337862015 @default.
• W2082933786 countsByYear W20829337862016 @default.
• W2082933786 countsByYear W20829337862017 @default.
• W2082933786 countsByYear W20829337862018 @default.
• W2082933786 countsByYear W20829337862020 @default.
• W2082933786 countsByYear W20829337862021 @default.
• W2082933786 countsByYear W20829337862022 @default.
• W2082933786 countsByYear W20829337862023 @default.
• W2082933786 crossrefType "journal-article" @default.
• W2082933786 hasAuthorship W2082933786A5002886067 @default.
• W2082933786 hasAuthorship W2082933786A5027994557 @default.
• W2082933786 hasAuthorship W2082933786A5032771596 @default.
• W2082933786 hasAuthorship W2082933786A5056971062 @default.
• W2082933786 hasAuthorship W2082933786A5071714593 @default.
• W2082933786 hasBestOaLocation W20829337862 @default.
• W2082933786 hasConcept C100701293 @default.
• W2082933786 hasConcept C129374314 @default.
• W2082933786 hasConcept C147483822 @default.
• W2082933786 hasConcept C150903083 @default.
• W2082933786 hasConcept C154317977 @default.
• W2082933786 hasConcept C167672396 @default.
• W2082933786 hasConcept C185592680 @default.
• W2082933786 hasConcept C19317047 @default.
• W2082933786 hasConcept C202751555 @default.
• W2082933786 hasConcept C203014093 @default.
• W2082933786 hasConcept C207001950 @default.
• W2082933786 hasConcept C2776090121 @default.
• W2082933786 hasConcept C502942594 @default.
• W2082933786 hasConcept C55493867 @default.
• W2082933786 hasConcept C59822182 @default.
• W2082933786 hasConcept C67662055 @default.
• W2082933786 hasConcept C81444415 @default.
• W2082933786 hasConcept C86803240 @default.
• W2082933786 hasConcept C8891405 @default.
• W2082933786 hasConcept C90375314 @default.
• W2082933786 hasConceptScore W2082933786C100701293 @default.
• W2082933786 hasConceptScore W2082933786C129374314 @default.
• W2082933786 hasConceptScore W2082933786C147483822 @default.
• W2082933786 hasConceptScore W2082933786C150903083 @default.
• W2082933786 hasConceptScore W2082933786C154317977 @default.
• W2082933786 hasConceptScore W2082933786C167672396 @default.
• W2082933786 hasConceptScore W2082933786C185592680 @default.
• W2082933786 hasConceptScore W2082933786C19317047 @default.
• W2082933786 hasConceptScore W2082933786C202751555 @default.

• next