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- W2082934515 abstract "Histone H1 inhibits the catalytic activity of topoisomerase I in vitro. The relaxation activity of the enzyme is partially inhibited at a molar ratio of one histone H1 molecule per 40 base pairs (bp) of DNA and completely inhibited at a molar ratio of one histone H1 molecule per 10 base pairs of DNA. Increasing the amount of enzyme at a constant histone H1 to DNA ratio antagonizes the inhibition. This indicates that topoisomerase I and histone H1 compete for binding sites on the substrate DNA molecules. Consistent with this we show on the sequence level that histone H1 inhibits the cleavage reaction of topoisomerase I on linear DNA fragments." @default.
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- W2082934515 date "1991-12-02" @default.
- W2082934515 modified "2023-09-26" @default.
- W2082934515 title "Histone H1 inhibits eukaryotic DNA topoisomerase I" @default.
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- W2082934515 doi "https://doi.org/10.1016/0014-5793(91)81357-e" @default.
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