FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2082935096> ?p ?o ?g. }

• W2082935096 endingPage "e76501" @default.
• W2082935096 startingPage "e76501" @default.
• W2082935096 abstract "The relationships among micro RNA-122 (miR-122) expression in the liver, hepatitis C virus (HCV) replication and hepatic damage were analyzed in three chimpanzees observed for 180 days after inoculation with HCV genotype 1a. Levels of miR-122 in the liver and serum were measured by real-time RT PCR in serial liver biopsies and serum samples. Hepatic miR-122 levels were normalized separately for each of three chimpanzees with small RNAs and microRNAs that are endogenous to the liver and are stably expressed. Two- to 4-fold rise in hepatic miR-122 levels was observed at the onset of HCV infection (the first 4 weeks) when HCV titers in the liver and serum increased rapidly in all three chimpanzees in concordance with in vitro data indicating the miR-122 significance for HCV replication. Between 10 to 14 weeks after inoculation, when hepatic and serum HCV RNA titers exceeded 3 logs and alanine aminotransferase (ALT) activity was elevated, hepatic miR-122 levels were in decline. Cumulative data derived from all three chimpanzees from 180 days of observation documented an inverse (negative) correlation between hepatic miR-122 and HCV RNA in the liver and serum and positive correlation between level of serum miR-122 and HCV replication. Subsequent rise of miR-122 level during HCV clearance and ALT normalization suggested a tri-phasic occurrence of the relationship among hepatic miR-122 expression, HCV replication and hepatic destruction, which was the most apparent in one chimpanzee but less evident in two other animals. In vivo kinetics of hepatic and serum miR-122, HCV replication and hepatic destruction reflects complexities of the virus-host interaction during the acute phase of HCV infection." @default.
• W2082935096 created "2016-06-24" @default.
• W2082935096 creator A5002561003 @default.
• W2082935096 creator A5058743300 @default.
• W2082935096 creator A5083883194 @default.
• W2082935096 date "2013-10-04" @default.
• W2082935096 modified "2023-10-18" @default.
• W2082935096 title "Kinetics of miR-122 Expression in the Liver during Acute HCV Infection" @default.
• W2082935096 cites W182012018 @default.
• W2082935096 cites W1965306643 @default.
• W2082935096 cites W1966141689 @default.
• W2082935096 cites W1967977640 @default.
• W2082935096 cites W1980268451 @default.
• W2082935096 cites W1980312274 @default.
• W2082935096 cites W1996867673 @default.
• W2082935096 cites W1999487724 @default.
• W2082935096 cites W2006309458 @default.
• W2082935096 cites W2009354010 @default.
• W2082935096 cites W2019825906 @default.
• W2082935096 cites W2026051181 @default.
• W2082935096 cites W2040621556 @default.
• W2082935096 cites W2047102263 @default.
• W2082935096 cites W2058493458 @default.
• W2082935096 cites W2066356959 @default.
• W2082935096 cites W2072442043 @default.
• W2082935096 cites W2072904045 @default.
• W2082935096 cites W2076941967 @default.
• W2082935096 cites W2105281461 @default.
• W2082935096 cites W2105423509 @default.
• W2082935096 cites W2108244474 @default.
• W2082935096 cites W2110525565 @default.
• W2082935096 cites W2114658861 @default.
• W2082935096 cites W2114741516 @default.
• W2082935096 cites W2149385948 @default.
• W2082935096 cites W2151868278 @default.
• W2082935096 cites W2157916750 @default.
• W2082935096 cites W2162877470 @default.
• W2082935096 cites W2164724442 @default.
• W2082935096 cites W2165532244 @default.
• W2082935096 doi "https://doi.org/10.1371/journal.pone.0076501" @default.
• W2082935096 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3790687" @default.
• W2082935096 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24124569" @default.
• W2082935096 hasPublicationYear "2013" @default.
• W2082935096 type Work @default.
• W2082935096 sameAs 2082935096 @default.
• W2082935096 citedByCount "25" @default.
• W2082935096 countsByYear W20829350962014 @default.
• W2082935096 countsByYear W20829350962015 @default.
• W2082935096 countsByYear W20829350962016 @default.
• W2082935096 countsByYear W20829350962018 @default.
• W2082935096 countsByYear W20829350962019 @default.
• W2082935096 countsByYear W20829350962020 @default.
• W2082935096 countsByYear W20829350962021 @default.
• W2082935096 countsByYear W20829350962022 @default.
• W2082935096 countsByYear W20829350962023 @default.
• W2082935096 crossrefType "journal-article" @default.
• W2082935096 hasAuthorship W2082935096A5002561003 @default.
• W2082935096 hasAuthorship W2082935096A5058743300 @default.
• W2082935096 hasAuthorship W2082935096A5083883194 @default.
• W2082935096 hasBestOaLocation W20829350961 @default.
• W2082935096 hasConcept C104317684 @default.
• W2082935096 hasConcept C126322002 @default.
• W2082935096 hasConcept C134018914 @default.
• W2082935096 hasConcept C140704245 @default.
• W2082935096 hasConcept C151678543 @default.
• W2082935096 hasConcept C159047783 @default.
• W2082935096 hasConcept C203014093 @default.
• W2082935096 hasConcept C2522874641 @default.
• W2082935096 hasConcept C2776408679 @default.
• W2082935096 hasConcept C2776455275 @default.
• W2082935096 hasConcept C2777510210 @default.
• W2082935096 hasConcept C2778606649 @default.
• W2082935096 hasConcept C2781463415 @default.
• W2082935096 hasConcept C32611913 @default.
• W2082935096 hasConcept C48023723 @default.
• W2082935096 hasConcept C53673613 @default.
• W2082935096 hasConcept C55493867 @default.
• W2082935096 hasConcept C71924100 @default.
• W2082935096 hasConcept C86803240 @default.
• W2082935096 hasConceptScore W2082935096C104317684 @default.
• W2082935096 hasConceptScore W2082935096C126322002 @default.
• W2082935096 hasConceptScore W2082935096C134018914 @default.
• W2082935096 hasConceptScore W2082935096C140704245 @default.
• W2082935096 hasConceptScore W2082935096C151678543 @default.
• W2082935096 hasConceptScore W2082935096C159047783 @default.
• W2082935096 hasConceptScore W2082935096C203014093 @default.
• W2082935096 hasConceptScore W2082935096C2522874641 @default.
• W2082935096 hasConceptScore W2082935096C2776408679 @default.
• W2082935096 hasConceptScore W2082935096C2776455275 @default.
• W2082935096 hasConceptScore W2082935096C2777510210 @default.
• W2082935096 hasConceptScore W2082935096C2778606649 @default.
• W2082935096 hasConceptScore W2082935096C2781463415 @default.
• W2082935096 hasConceptScore W2082935096C32611913 @default.
• W2082935096 hasConceptScore W2082935096C48023723 @default.
• W2082935096 hasConceptScore W2082935096C53673613 @default.
• W2082935096 hasConceptScore W2082935096C55493867 @default.
• W2082935096 hasConceptScore W2082935096C71924100 @default.
• W2082935096 hasConceptScore W2082935096C86803240 @default.

• next