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- W2082935377 abstract "Earlier investigations of pneumococcal transformation revealed a function (hex + ) responsible for severely reducing the transformation yield of certain markers. A mutational alteration (hex - ) responsible for the loss of this function has been transferred into a hex + strain to permit a comparison of the hex + and hex - phenotypes in an isogenic background. The loss of the hex + function results both in a loss of the capacity to eliminate the low efficiency markers in transformation and a substantial increase in the spontaneous mutation rate. These properties of the hex - strain could result from the loss of a capacity to eliminate certain classes of mismatched base pairs that occur as intermediates in both transformation and mutagenesis." @default.
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- W2082935377 date "1973-12-01" @default.
- W2082935377 modified "2023-09-24" @default.
- W2082935377 title "Marker Discrimination in Transformation and Mutation of Pneumococcus" @default.
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- W2082935377 doi "https://doi.org/10.1073/pnas.70.12.3541" @default.
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