FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2082942255> ?p ?o ?g. }

• W2082942255 endingPage "201" @default.
• W2082942255 startingPage "191" @default.
• W2082942255 abstract "Glutathione peroxidase-4 (GPx4) is a multifunctional selenoprotein expressed as mitochondrial, cytosolic, or nuclear isoforms. As a catalytically active enzyme it has been implicated in antioxidative defense, but during sperm development it functions as a structural protein. GPx4 null mice die in utero at midgestation and knockdown of GPx4 during embryogenesis disturbs brain development. To explore the cerebral function of GPx4 we profiled cell-specific enzyme expression at various stages of perinatal brain maturation and investigated its regulation following brain injury by immunohistochemistry, in situ hybridization, and quantitative RT-PCR. Large amounts of GPx4 mRNA were detected in all neuronal layers during perinatal brain development but expression became restricted during postnatal maturation. In adult brain mitochondrial and cytosolic GPx4 isoforms were detected in neurons of cerebral cortex, hippocampus, and cerebellum whereas glial cells were devoid of GPx4. Following selective brain injury expression of the enzyme was upregulated in reactive astrocytes of lesioned areas and deafferented regions but not in neurons. Selective knockdown of GPx4 by small interfering RNA induced depletion of phosphatidylinositol-(4,5)-bisphosphate in the neuronal plasma membrane and subsequently apoptosis as indicated by caspase-3 activation. We hypothesize that astrocytic upregulation of GPx4 in response to injury is part of a protective cascade counteracting further cell damage." @default.
• W2082942255 created "2016-06-24" @default.
• W2082942255 creator A5048650129 @default.
• W2082942255 creator A5064301762 @default.
• W2082942255 creator A5084392208 @default.
• W2082942255 creator A5084969160 @default.
• W2082942255 date "2007-07-01" @default.
• W2082942255 modified "2023-10-03" @default.
• W2082942255 title "Role for glutathione peroxidase-4 in brain development and neuronal apoptosis: Specific induction of enzyme expression in reactive astrocytes following brain injury" @default.
• W2082942255 cites W1506594192 @default.
• W2082942255 cites W1510592624 @default.
• W2082942255 cites W1544883203 @default.
• W2082942255 cites W1625092822 @default.
• W2082942255 cites W1963835954 @default.
• W2082942255 cites W1966920840 @default.
• W2082942255 cites W1969436148 @default.
• W2082942255 cites W1975918556 @default.
• W2082942255 cites W1977416718 @default.
• W2082942255 cites W1997194688 @default.
• W2082942255 cites W1999062352 @default.
• W2082942255 cites W2001505200 @default.
• W2082942255 cites W2017906971 @default.
• W2082942255 cites W2019910142 @default.
• W2082942255 cites W2020865685 @default.
• W2082942255 cites W2024381211 @default.
• W2082942255 cites W2026468124 @default.
• W2082942255 cites W2028938618 @default.
• W2082942255 cites W2032405173 @default.
• W2082942255 cites W2035983603 @default.
• W2082942255 cites W2040564306 @default.
• W2082942255 cites W2047440104 @default.
• W2082942255 cites W2049478907 @default.
• W2082942255 cites W2056625411 @default.
• W2082942255 cites W2060366523 @default.
• W2082942255 cites W2068972343 @default.
• W2082942255 cites W2069485678 @default.
• W2082942255 cites W2074901704 @default.
• W2082942255 cites W2091926090 @default.
• W2082942255 cites W2138138539 @default.
• W2082942255 cites W2139068942 @default.
• W2082942255 cites W2146882474 @default.
• W2082942255 cites W2152399201 @default.
• W2082942255 cites W2165072468 @default.
• W2082942255 cites W2315812344 @default.
• W2082942255 cites W4300932895 @default.
• W2082942255 cites W995921749 @default.
• W2082942255 doi "https://doi.org/10.1016/j.freeradbiomed.2007.03.033" @default.
• W2082942255 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17603929" @default.
• W2082942255 hasPublicationYear "2007" @default.
• W2082942255 type Work @default.
• W2082942255 sameAs 2082942255 @default.
• W2082942255 citedByCount "88" @default.
• W2082942255 countsByYear W20829422552012 @default.
• W2082942255 countsByYear W20829422552013 @default.
• W2082942255 countsByYear W20829422552014 @default.
• W2082942255 countsByYear W20829422552015 @default.
• W2082942255 countsByYear W20829422552016 @default.
• W2082942255 countsByYear W20829422552017 @default.
• W2082942255 countsByYear W20829422552018 @default.
• W2082942255 countsByYear W20829422552019 @default.
• W2082942255 countsByYear W20829422552020 @default.
• W2082942255 countsByYear W20829422552021 @default.
• W2082942255 countsByYear W20829422552022 @default.
• W2082942255 countsByYear W20829422552023 @default.
• W2082942255 crossrefType "journal-article" @default.
• W2082942255 hasAuthorship W2082942255A5048650129 @default.
• W2082942255 hasAuthorship W2082942255A5064301762 @default.
• W2082942255 hasAuthorship W2082942255A5084392208 @default.
• W2082942255 hasAuthorship W2082942255A5084969160 @default.
• W2082942255 hasConcept C104317684 @default.
• W2082942255 hasConcept C127561419 @default.
• W2082942255 hasConcept C150194340 @default.
• W2082942255 hasConcept C158086472 @default.
• W2082942255 hasConcept C173396325 @default.
• W2082942255 hasConcept C181199279 @default.
• W2082942255 hasConcept C190283241 @default.
• W2082942255 hasConcept C2778760513 @default.
• W2082942255 hasConcept C2781264002 @default.
• W2082942255 hasConcept C538909803 @default.
• W2082942255 hasConcept C55493867 @default.
• W2082942255 hasConcept C81439078 @default.
• W2082942255 hasConcept C86803240 @default.
• W2082942255 hasConcept C95444343 @default.
• W2082942255 hasConceptScore W2082942255C104317684 @default.
• W2082942255 hasConceptScore W2082942255C127561419 @default.
• W2082942255 hasConceptScore W2082942255C150194340 @default.
• W2082942255 hasConceptScore W2082942255C158086472 @default.
• W2082942255 hasConceptScore W2082942255C173396325 @default.
• W2082942255 hasConceptScore W2082942255C181199279 @default.
• W2082942255 hasConceptScore W2082942255C190283241 @default.
• W2082942255 hasConceptScore W2082942255C2778760513 @default.
• W2082942255 hasConceptScore W2082942255C2781264002 @default.
• W2082942255 hasConceptScore W2082942255C538909803 @default.
• W2082942255 hasConceptScore W2082942255C55493867 @default.
• W2082942255 hasConceptScore W2082942255C81439078 @default.
• W2082942255 hasConceptScore W2082942255C86803240 @default.
• W2082942255 hasConceptScore W2082942255C95444343 @default.
• W2082942255 hasIssue "2" @default.

• next