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- W2082946896 abstract "Nerve growth factor (NGF) is one of an increasing number of growth factors that has been recognized as being essential for the survival and maintenance of specific types of cells. This chapter discusses the nerve growth factor from mouse submaxillary gland, the high molecular weight form of NGF (7 S NGF), the biosynthesis of NGF, snake venom NGF, and the mechanism of action of NGF. Two types of nerve cells are absolutely dependent on NGF for their normal development; the adrenergic neurons in the sympathetic ganglia and one of the two types of neurons in embryonic sensory ganglia. Several roles have been proposed for the 7 S NGF complex, such as NGF as the critical permissive agent in the growth of certain nerve cells, and as a messenger relaying information from the periphery of the nerve cell to its cell body. However, interaction of NGF with this receptor that leads to neurite outgrowth during ontogenetic development, is not yet understood, nor is the process, which leads to internalization of NGF and increased neurotransmitter synthesis at a later stage of development, or in the mature neuron. The chapter suggests that elucidation of any one of these issues will greatly advance our understanding of this important growth factor." @default.
- W2082946896 created "2016-06-24" @default.
- W2082946896 creator A5027043773 @default.
- W2082946896 creator A5044790288 @default.
- W2082946896 date "1977-01-01" @default.
- W2082946896 modified "2023-10-16" @default.
- W2082946896 title "Nerve Growth Factor" @default.
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