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- W2082947962 abstract "Our previous studies indicated that the toxicity of chloro- or bromo-methanes is potentiated by chlordecone (CD). The present work was conducted to study the effect of prior dietary exposure to CD on toxicity of bromoform. Male S-D rats (175-200 g) were fed 0 or 10 ppm CD in the powdered ration for 15 days. Bromoform (25 to 300 microliters/kg) was given i.p. on day 15. 24 h later, hepatotoxicity was assessed by functional, biochemical and histopathological parameters. Excretion of phenolphthalein glucuronide in bile and the rate of bile flow were unaltered by either bromoform or CD-bromoform combination. Serum enzymes (GPT, GOT and isocitric dehydrogenase (ICD) were also not significantly elevated by any treatment. The results suggest that, unlike chloroform, CHBr3 does not act as a potent hepatotoxin and that its effects are not potentiated by CD to any significant extent." @default.
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- W2082947962 date "1983-02-01" @default.
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- W2082947962 title "Absence of potentiation of bromoform hepatotoxicity and lethality by chlordecone" @default.
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- W2082947962 doi "https://doi.org/10.1016/0378-4274(83)90224-2" @default.
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