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- W2082951718 abstract "The Trichomonas vaginalis genome encodes up to 60 000 genes, many of which stem from genome duplication events. Paralogous copies thus accompany most T. vaginalis genes, a phenomenon that limits genetic manipulation. We characterized one of the parasite's most abundant hydrogenosomal membrane proteins, TvHMP23, which is phylogenetically distinct from canonical metabolite carriers, and which localizes to the inner hydrogenosomal membrane as shown through sub-organellar fractionation and protease protection assays. Knockout of Tvhmp23 through insertion of the selectable neomycin marker led to a size increase of hydrogenosomes, the first knockout-induced phenotypes reported for Trichomonas, but no growth impairment. The transcriptional response of its four paralogous copies then analyzed revealed that they are not up-regulated, and hence do not compensate for the Tvhmp23 knockout." @default.
- W2082951718 created "2016-06-24" @default.
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- W2082951718 date "2013-03-13" @default.
- W2082951718 modified "2023-10-12" @default.
- W2082951718 title "Knockout of the abundant <i>Trichomonas vaginalis</i> hydrogenosomal membrane protein <i>Tv</i> HMP23 increases hydrogenosome size but induces no compensatory up‐regulation of paralogous copies" @default.
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- W2082951718 doi "https://doi.org/10.1016/j.febslet.2013.03.001" @default.
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