FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2082978049> ?p ?o ?g. }

• W2082978049 endingPage "4815" @default.
• W2082978049 startingPage "4804" @default.
• W2082978049 abstract "ABSTRACT Cells use complex mechanisms to regulate glucose transport and metabolism to achieve optimal energy and biomass production while avoiding accumulation of toxic metabolites. Glucose transport and glycolytic metabolism carry the risk of the buildup of phosphosugars, which can inhibit growth at high concentrations. Many enteric bacteria cope with phosphosugar accumulation and associated stress (i.e., sugar-phosphate stress) by producing a small RNA (sRNA) regulator, SgrS, which decreases phosphosugar accumulation in part by repressing translation of sugar transporter mRNAs ( ptsG and manXYZ ) and enhancing translation of a sugar phosphatase mRNA ( yigL ). Despite a molecular understanding of individual target regulation by SgrS, previously little was known about how coordinated regulation of these multiple targets contributes to the rescue of cell growth during sugar-phosphate stress. This study examines how SgrS regulation of different targets impacts growth under different nutritional conditions when sugar-phosphate stress is induced. The severity of stress-associated growth inhibition depended on nutrient availability. Stress in nutrient-rich media necessitated SgrS regulation of only sugar transporter mRNAs ( ptsG or manXYZ ). However, repression of transporter mRNAs was insufficient for growth rescue during stress in nutrient-poor media; here SgrS regulation of the phosphatase ( yigL ) and as-yet-undefined targets also contributed to growth rescue. The results of this study imply that regulation of only a subset of an sRNA's targets may be important in a given environment. Further, the results suggest that SgrS and perhaps other sRNAs are flexible regulators that modulate expression of multigene regulons to allow cells to adapt to an array of stress conditions." @default.
• W2082978049 created "2016-06-24" @default.
• W2082978049 creator A5002118503 @default.
• W2082978049 creator A5006548294 @default.
• W2082978049 date "2013-11-01" @default.
• W2082978049 modified "2023-10-16" @default.
• W2082978049 title "Physiological Consequences of Multiple-Target Regulation by the Small RNA SgrS in Escherichia coli" @default.
• W2082978049 cites W1652028037 @default.
• W2082978049 cites W1784113312 @default.
• W2082978049 cites W1879712221 @default.
• W2082978049 cites W1964843324 @default.
• W2082978049 cites W1967946076 @default.
• W2082978049 cites W1972585214 @default.
• W2082978049 cites W1986459391 @default.
• W2082978049 cites W1996316886 @default.
• W2082978049 cites W1998137451 @default.
• W2082978049 cites W2010447483 @default.
• W2082978049 cites W2014372073 @default.
• W2082978049 cites W2034705099 @default.
• W2082978049 cites W2046374424 @default.
• W2082978049 cites W2055812912 @default.
• W2082978049 cites W2058559800 @default.
• W2082978049 cites W2075619582 @default.
• W2082978049 cites W2076061954 @default.
• W2082978049 cites W2082343767 @default.
• W2082978049 cites W2097197928 @default.
• W2082978049 cites W2098508116 @default.
• W2082978049 cites W2100651961 @default.
• W2082978049 cites W2104789037 @default.
• W2082978049 cites W2113394693 @default.
• W2082978049 cites W2115419697 @default.
• W2082978049 cites W2119338907 @default.
• W2082978049 cites W2130394726 @default.
• W2082978049 cites W2132848412 @default.
• W2082978049 cites W2134412337 @default.
• W2082978049 cites W2136670217 @default.
• W2082978049 cites W2144241087 @default.
• W2082978049 cites W2148277388 @default.
• W2082978049 cites W2150093433 @default.
• W2082978049 cites W2150623405 @default.
• W2082978049 cites W2153949128 @default.
• W2082978049 cites W2166374078 @default.
• W2082978049 cites W2168920221 @default.
• W2082978049 cites W415394281 @default.
• W2082978049 doi "https://doi.org/10.1128/jb.00722-13" @default.
• W2082978049 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3807494" @default.
• W2082978049 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23873911" @default.
• W2082978049 hasPublicationYear "2013" @default.
• W2082978049 type Work @default.
• W2082978049 sameAs 2082978049 @default.
• W2082978049 citedByCount "45" @default.
• W2082978049 countsByYear W20829780492013 @default.
• W2082978049 countsByYear W20829780492014 @default.
• W2082978049 countsByYear W20829780492015 @default.
• W2082978049 countsByYear W20829780492016 @default.
• W2082978049 countsByYear W20829780492017 @default.
• W2082978049 countsByYear W20829780492018 @default.
• W2082978049 countsByYear W20829780492019 @default.
• W2082978049 countsByYear W20829780492020 @default.
• W2082978049 countsByYear W20829780492021 @default.
• W2082978049 countsByYear W20829780492022 @default.
• W2082978049 crossrefType "journal-article" @default.
• W2082978049 hasAuthorship W2082978049A5002118503 @default.
• W2082978049 hasAuthorship W2082978049A5006548294 @default.
• W2082978049 hasBestOaLocation W20829780491 @default.
• W2082978049 hasConcept C104317684 @default.
• W2082978049 hasConcept C105580179 @default.
• W2082978049 hasConcept C149364088 @default.
• W2082978049 hasConcept C150194340 @default.
• W2082978049 hasConcept C150903083 @default.
• W2082978049 hasConcept C161573976 @default.
• W2082978049 hasConcept C165864922 @default.
• W2082978049 hasConcept C178666793 @default.
• W2082978049 hasConcept C181199279 @default.
• W2082978049 hasConcept C186310378 @default.
• W2082978049 hasConcept C2776030549 @default.
• W2082978049 hasConcept C2777108408 @default.
• W2082978049 hasConcept C2777132085 @default.
• W2082978049 hasConcept C2779306644 @default.
• W2082978049 hasConcept C2779341050 @default.
• W2082978049 hasConcept C2780535078 @default.
• W2082978049 hasConcept C55493867 @default.
• W2082978049 hasConcept C62361671 @default.
• W2082978049 hasConcept C62478195 @default.
• W2082978049 hasConcept C67705224 @default.
• W2082978049 hasConcept C6929976 @default.
• W2082978049 hasConcept C86803240 @default.
• W2082978049 hasConcept C95444343 @default.
• W2082978049 hasConceptScore W2082978049C104317684 @default.
• W2082978049 hasConceptScore W2082978049C105580179 @default.
• W2082978049 hasConceptScore W2082978049C149364088 @default.
• W2082978049 hasConceptScore W2082978049C150194340 @default.
• W2082978049 hasConceptScore W2082978049C150903083 @default.
• W2082978049 hasConceptScore W2082978049C161573976 @default.
• W2082978049 hasConceptScore W2082978049C165864922 @default.
• W2082978049 hasConceptScore W2082978049C178666793 @default.
• W2082978049 hasConceptScore W2082978049C181199279 @default.
• W2082978049 hasConceptScore W2082978049C186310378 @default.

• next