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• W2082988430 endingPage "52" @default.
• W2082988430 startingPage "32" @default.
• W2082988430 abstract "Dry powder inhaler (DPI) products have traditionally comprised a simple formulation of micronised drug mixed with a carrier excipient, typically lactose monohydrate. The presence of the carrier is aimed at overcoming issues of poor flowability and dispersibility, associated with the cohesive nature of small, micronised active pharmaceutical ingredient (API) particles. Both the powder blend and the DPI device must be carefully designed so as to ensure detachment of the micronised drug from the carrier excipient on inhalation. Over the last two decades there has been a significant body of research undertaken on the design of carrier-free formulations for DPI products. Many of these formulations are based on sophisticated particle engineering techniques; a common aim in formulation design of carrier-free products being to reduce the intrinsic cohesion of the particles, while maximising dispersion and delivery from the inhaler. In tandem with the development of alternative formulations has been the development of devices designed to ensure the efficient delivery and dispersion of carrier-free powder on inhalation. In this review we examine approaches to both the powder formulation and inhaler design for carrier-free DPI products." @default.
• W2082988430 created "2016-06-24" @default.
• W2082988430 creator A5006695085 @default.
• W2082988430 creator A5042367583 @default.
• W2082988430 creator A5046416793 @default.
• W2082988430 creator A5073383878 @default.
• W2082988430 date "2014-08-01" @default.
• W2082988430 modified "2023-10-15" @default.
• W2082988430 title "Dry powders for oral inhalation free of lactose carrier particles" @default.
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