Matches in SemOpenAlex for { <https://semopenalex.org/work/W2082994402> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W2082994402 endingPage "864" @default.
- W2082994402 startingPage "861" @default.
- W2082994402 abstract "A novel nitration process was developed for the production of 4-(4-methoxy-3-nitrophenyl)morpholine. Crude 4-(4-methoxyphenyl)morpholine produced in step 1 was converted to its nitric acid salt. The nitration reaction was carried out by adding a dichloromethane solution of the isolated salt to concentrated sulfuric acid. This protocol provided an easy and reliable way to obtain a 1:1 molar ratio of the substrate and nitric acid in the reaction mixture and was proven to be the most effective method to prevent under-/over-nitration. The incorporation of the protocol into the process resulted in substantial improvement of the robustness and safety profile of the whole process. In addition, 59% overall yield improvement, 30% capacity increase, 40% waste reduction, and simplified operations were achieved. A detailed thermal hazard analysis of the process was also performed." @default.
- W2082994402 created "2016-06-24" @default.
- W2082994402 creator A5008513256 @default.
- W2082994402 creator A5018579754 @default.
- W2082994402 creator A5024939596 @default.
- W2082994402 creator A5049301731 @default.
- W2082994402 creator A5063724668 @default.
- W2082994402 creator A5085021498 @default.
- W2082994402 date "2007-07-24" @default.
- W2082994402 modified "2023-09-26" @default.
- W2082994402 title "A Novel, Safe, and Robust Nitration Process for the Synthesis of 4-(4-Methoxy-3-nitrophenyl)morpholine" @default.
- W2082994402 doi "https://doi.org/10.1021/op700074k" @default.
- W2082994402 hasPublicationYear "2007" @default.
- W2082994402 type Work @default.
- W2082994402 sameAs 2082994402 @default.
- W2082994402 citedByCount "6" @default.
- W2082994402 countsByYear W20829944022013 @default.
- W2082994402 countsByYear W20829944022016 @default.
- W2082994402 countsByYear W20829944022021 @default.
- W2082994402 crossrefType "journal-article" @default.
- W2082994402 hasAuthorship W2082994402A5008513256 @default.
- W2082994402 hasAuthorship W2082994402A5018579754 @default.
- W2082994402 hasAuthorship W2082994402A5024939596 @default.
- W2082994402 hasAuthorship W2082994402A5049301731 @default.
- W2082994402 hasAuthorship W2082994402A5063724668 @default.
- W2082994402 hasAuthorship W2082994402A5085021498 @default.
- W2082994402 hasConcept C134121241 @default.
- W2082994402 hasConcept C178790620 @default.
- W2082994402 hasConcept C185592680 @default.
- W2082994402 hasConcept C191897082 @default.
- W2082994402 hasConcept C192562407 @default.
- W2082994402 hasConcept C2775856698 @default.
- W2082994402 hasConcept C2776371256 @default.
- W2082994402 hasConcept C2778199549 @default.
- W2082994402 hasConcept C2778504605 @default.
- W2082994402 hasConcept C2780400988 @default.
- W2082994402 hasConcept C2780471494 @default.
- W2082994402 hasConcept C2781056017 @default.
- W2082994402 hasConceptScore W2082994402C134121241 @default.
- W2082994402 hasConceptScore W2082994402C178790620 @default.
- W2082994402 hasConceptScore W2082994402C185592680 @default.
- W2082994402 hasConceptScore W2082994402C191897082 @default.
- W2082994402 hasConceptScore W2082994402C192562407 @default.
- W2082994402 hasConceptScore W2082994402C2775856698 @default.
- W2082994402 hasConceptScore W2082994402C2776371256 @default.
- W2082994402 hasConceptScore W2082994402C2778199549 @default.
- W2082994402 hasConceptScore W2082994402C2778504605 @default.
- W2082994402 hasConceptScore W2082994402C2780400988 @default.
- W2082994402 hasConceptScore W2082994402C2780471494 @default.
- W2082994402 hasConceptScore W2082994402C2781056017 @default.
- W2082994402 hasIssue "5" @default.
- W2082994402 hasLocation W20829944021 @default.
- W2082994402 hasOpenAccess W2082994402 @default.
- W2082994402 hasPrimaryLocation W20829944021 @default.
- W2082994402 hasRelatedWork W2011662521 @default.
- W2082994402 hasRelatedWork W2318612195 @default.
- W2082994402 hasRelatedWork W2348484059 @default.
- W2082994402 hasRelatedWork W2354973326 @default.
- W2082994402 hasRelatedWork W2370885479 @default.
- W2082994402 hasRelatedWork W2379948255 @default.
- W2082994402 hasRelatedWork W2393933271 @default.
- W2082994402 hasRelatedWork W2394242218 @default.
- W2082994402 hasRelatedWork W2399649915 @default.
- W2082994402 hasRelatedWork W2950813734 @default.
- W2082994402 hasVolume "11" @default.
- W2082994402 isParatext "false" @default.
- W2082994402 isRetracted "false" @default.
- W2082994402 magId "2082994402" @default.
- W2082994402 workType "article" @default.