Matches in SemOpenAlex for { <https://semopenalex.org/work/W2082997198> ?p ?o ?g. }
Showing items 1 to 50 of
50
with 100 items per page.
- W2082997198 endingPage "101" @default.
- W2082997198 startingPage "92" @default.
- W2082997198 abstract "Bone marrow transplantation has been used to treat children with a variety of malignant, hematologic, immunologic, and genetic disorders. It is currently the treatment of choice for patients with certain types of leukemia (eg, acute myelogenous leukemia, chronic myelogenous leukemia, juvenile chronic myelogenous leukemia), severe aplastic anemia, severe combined immunodeficiency syndrome, and select genetic diseases (eg, Hurler's syndrome, osteopetro-sis). However, most children who would benefit from a transplant do not have an HLA-identical sibling to serve as the marrow donor. Several strategies have been developed to circumvent this problem including the utilization of unrelated volunteers or partially matched family members as donors, and autologous bone marrow or peripheral stem cell transplants. Progress has also been made in reducing the occurrence of transplant-related complications. The incidence of cytomegalovirus disease has diminished with the use of screened blood products and antiviral drug therapy. The risk of bacterial infections has also been reduced by the prophylactic administration of antibiotics and intravenous gammaglobulin. In addition, cytokines such as recombinant human granulocyte-macrophage colony-stimulating factor may promote early neutrophil recovery after transplantation, providing additional protection against infection. Cytokines may also prolong the survival of patients with graft failure. New methods have been reported for the prevention and treatment of graft-versus-host disease by the selective elimination of T lymphocytes from the marrow before transplantation or from the blood after transplantation. For children who undergo transplantation because of an oncologic disorder, relapse remains a major cause of treatment failure. The use of marrow purging techniques and biologic response modifiers may further improve the outlook for these patients." @default.
- W2082997198 created "2016-06-24" @default.
- W2082997198 creator A5003161764 @default.
- W2082997198 creator A5052995460 @default.
- W2082997198 date "1992-02-01" @default.
- W2082997198 modified "2023-09-26" @default.
- W2082997198 title "Pediatric bone marrow transplantation" @default.
- W2082997198 doi "https://doi.org/10.1097/00008480-199202000-00015" @default.
- W2082997198 hasPublicationYear "1992" @default.
- W2082997198 type Work @default.
- W2082997198 sameAs 2082997198 @default.
- W2082997198 citedByCount "1" @default.
- W2082997198 crossrefType "journal-article" @default.
- W2082997198 hasAuthorship W2082997198A5003161764 @default.
- W2082997198 hasAuthorship W2082997198A5052995460 @default.
- W2082997198 hasConcept C126322002 @default.
- W2082997198 hasConcept C203014093 @default.
- W2082997198 hasConcept C2776960273 @default.
- W2082997198 hasConcept C2778461978 @default.
- W2082997198 hasConcept C2780007613 @default.
- W2082997198 hasConcept C2911091166 @default.
- W2082997198 hasConcept C71924100 @default.
- W2082997198 hasConceptScore W2082997198C126322002 @default.
- W2082997198 hasConceptScore W2082997198C203014093 @default.
- W2082997198 hasConceptScore W2082997198C2776960273 @default.
- W2082997198 hasConceptScore W2082997198C2778461978 @default.
- W2082997198 hasConceptScore W2082997198C2780007613 @default.
- W2082997198 hasConceptScore W2082997198C2911091166 @default.
- W2082997198 hasConceptScore W2082997198C71924100 @default.
- W2082997198 hasIssue "1" @default.
- W2082997198 hasLocation W20829971981 @default.
- W2082997198 hasOpenAccess W2082997198 @default.
- W2082997198 hasPrimaryLocation W20829971981 @default.
- W2082997198 hasRelatedWork W107355686 @default.
- W2082997198 hasRelatedWork W16036224 @default.
- W2082997198 hasRelatedWork W2005774754 @default.
- W2082997198 hasRelatedWork W2063301586 @default.
- W2082997198 hasRelatedWork W2093870260 @default.
- W2082997198 hasRelatedWork W2140740396 @default.
- W2082997198 hasRelatedWork W2430567572 @default.
- W2082997198 hasRelatedWork W3155570094 @default.
- W2082997198 hasRelatedWork W80868084 @default.
- W2082997198 hasRelatedWork W2103761397 @default.
- W2082997198 hasVolume "4" @default.
- W2082997198 isParatext "false" @default.
- W2082997198 isRetracted "false" @default.
- W2082997198 magId "2082997198" @default.
- W2082997198 workType "article" @default.