FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2083004581> ?p ?o ?g. }

• W2083004581 endingPage "736" @default.
• W2083004581 startingPage "729" @default.
• W2083004581 abstract "Amphotropic recombinant retroviruses were generated carrying sequences encoding human adenosine deaminase (ADA). Transcription of the human ADA gene was under control of a hybrid long terminal repeat in which the enhancer from the Moloney murine leukemia virus was replaced by an enhancer from the F101 host-range mutant of polyoma virus. Hemopoietic stem cells in murine bone marrow were infected with this virus under defined culture conditions. As a result, 59% of day-12 colony forming unit spleen (CFU-S) stem cells became infected without any in vitro selection. Infected CFU-S were shown to express human ADA before transplantation and this expression sustained upon in vivo maturation. Mice transplanted with infected bone marrow exhibited human ADA expression in lymphoid, myeloid, and erythroid cell types. Moreover, human ADA expression persisted in secondary and tertiary transplanted recipients showing that human ADA-expressing cells were derived from pluripotent stem cells. These characteristics of our amphotropic viruses make them promising tools in gene therapy protocols for the treatment of severe combined immunodeficiency caused by ADA deficiency. In this respect it is also relevant that the viral vector that served as backbone for the ADA vector was previously shown to be nonleukemogenic." @default.
• W2083004581 created "2016-06-24" @default.
• W2083004581 creator A5005071520 @default.
• W2083004581 creator A5007454863 @default.
• W2083004581 creator A5012988223 @default.
• W2083004581 creator A5018273844 @default.
• W2083004581 creator A5034334503 @default.
• W2083004581 creator A5044505683 @default.
• W2083004581 creator A5072019864 @default.
• W2083004581 date "1990-09-01" @default.
• W2083004581 modified "2023-09-23" @default.
• W2083004581 title "Expression of human adenosine deaminase in mice transplanted with hemopoietic stem cells infected with amphotropic retroviruses." @default.
• W2083004581 cites W1546024790 @default.
• W2083004581 cites W1583576521 @default.
• W2083004581 cites W1657933159 @default.
• W2083004581 cites W1801420105 @default.
• W2083004581 cites W1848247024 @default.
• W2083004581 cites W1868517480 @default.
• W2083004581 cites W1947669382 @default.
• W2083004581 cites W1954929088 @default.
• W2083004581 cites W1965372133 @default.
• W2083004581 cites W1971502404 @default.
• W2083004581 cites W1985192507 @default.
• W2083004581 cites W1990367849 @default.
• W2083004581 cites W199686417 @default.
• W2083004581 cites W1997110527 @default.
• W2083004581 cites W1999516176 @default.
• W2083004581 cites W2016647073 @default.
• W2083004581 cites W2022205235 @default.
• W2083004581 cites W2023241219 @default.
• W2083004581 cites W2026384193 @default.
• W2083004581 cites W2035307466 @default.
• W2083004581 cites W2036337312 @default.
• W2083004581 cites W2037719060 @default.
• W2083004581 cites W2045679225 @default.
• W2083004581 cites W2051806824 @default.
• W2083004581 cites W2069416922 @default.
• W2083004581 cites W2075817710 @default.
• W2083004581 cites W2091757239 @default.
• W2083004581 cites W2091987058 @default.
• W2083004581 cites W2095787255 @default.
• W2083004581 cites W2099369209 @default.
• W2083004581 doi "https://doi.org/10.1084/jem.172.3.729" @default.
• W2083004581 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2188546" @default.
• W2083004581 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1974914" @default.
• W2083004581 hasPublicationYear "1990" @default.
• W2083004581 type Work @default.
• W2083004581 sameAs 2083004581 @default.
• W2083004581 citedByCount "51" @default.
• W2083004581 countsByYear W20830045812013 @default.
• W2083004581 crossrefType "journal-article" @default.
• W2083004581 hasAuthorship W2083004581A5005071520 @default.
• W2083004581 hasAuthorship W2083004581A5007454863 @default.
• W2083004581 hasAuthorship W2083004581A5012988223 @default.
• W2083004581 hasAuthorship W2083004581A5018273844 @default.
• W2083004581 hasAuthorship W2083004581A5034334503 @default.
• W2083004581 hasAuthorship W2083004581A5044505683 @default.
• W2083004581 hasAuthorship W2083004581A5072019864 @default.
• W2083004581 hasBestOaLocation W20830045811 @default.
• W2083004581 hasConcept C104317684 @default.
• W2083004581 hasConcept C107459253 @default.
• W2083004581 hasConcept C109159458 @default.
• W2083004581 hasConcept C111599444 @default.
• W2083004581 hasConcept C141071460 @default.
• W2083004581 hasConcept C145103041 @default.
• W2083004581 hasConcept C153911025 @default.
• W2083004581 hasConcept C159047783 @default.
• W2083004581 hasConcept C201750760 @default.
• W2083004581 hasConcept C203014093 @default.
• W2083004581 hasConcept C2522874641 @default.
• W2083004581 hasConcept C2776991684 @default.
• W2083004581 hasConcept C2778431562 @default.
• W2083004581 hasConcept C2779282312 @default.
• W2083004581 hasConcept C2779468541 @default.
• W2083004581 hasConcept C2779562191 @default.
• W2083004581 hasConcept C2780007613 @default.
• W2083004581 hasConcept C28328180 @default.
• W2083004581 hasConcept C2911091166 @default.
• W2083004581 hasConcept C32470452 @default.
• W2083004581 hasConcept C34628245 @default.
• W2083004581 hasConcept C40767141 @default.
• W2083004581 hasConcept C502942594 @default.
• W2083004581 hasConcept C54355233 @default.
• W2083004581 hasConcept C55493867 @default.
• W2083004581 hasConcept C71924100 @default.
• W2083004581 hasConcept C86803240 @default.
• W2083004581 hasConcept C95444343 @default.
• W2083004581 hasConceptScore W2083004581C104317684 @default.
• W2083004581 hasConceptScore W2083004581C107459253 @default.
• W2083004581 hasConceptScore W2083004581C109159458 @default.
• W2083004581 hasConceptScore W2083004581C111599444 @default.
• W2083004581 hasConceptScore W2083004581C141071460 @default.
• W2083004581 hasConceptScore W2083004581C145103041 @default.
• W2083004581 hasConceptScore W2083004581C153911025 @default.
• W2083004581 hasConceptScore W2083004581C159047783 @default.
• W2083004581 hasConceptScore W2083004581C201750760 @default.
• W2083004581 hasConceptScore W2083004581C203014093 @default.
• W2083004581 hasConceptScore W2083004581C2522874641 @default.

• next