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• W2083007831 abstract "The harmful effects of UVA radiation (320–400 nm) on the skin have been related to the generation of reactive oxygen species. Pheomelanin, the pigment characteristic of fair-skinned individuals, amplifies these effects. In vitro, in the presence of photosensitizing agents, UVA light produces singlet oxygen, which reacts with several targets. We have investigated a possible correlation between melanin-type and the antioxidant defense system after UV, focusing on the activities of superoxide dismutase and catalase, which correlated with the phototype of epidermal reconstructs. UVA was more effective than UVB in damaging these enzymatic activities, especially catalase. Furthermore, UVA irradiation induced a free-radical-mediated damage in the cells, leading to an oxidation of cell proteins. On catalase, synthetic pheomelanin amplified this effect on specific targets, such as residues of tryptophan and methionine. UVA irradiation of low phototype reconstructed epidermis and of U937 through synthetic pheomelanin induced a modification in the electrophoretic properties of native catalase, which was counteracted by histidine, a quencher of singlet oxygen. These results demonstrate that pheomelanin could act as a photosensitizing agent, following UVA irradiation, inducing charge modifications of native catalase, by a mechanism involving singlet oxygen or its downstream products. The harmful effects of UVA radiation (320–400 nm) on the skin have been related to the generation of reactive oxygen species. Pheomelanin, the pigment characteristic of fair-skinned individuals, amplifies these effects. In vitro, in the presence of photosensitizing agents, UVA light produces singlet oxygen, which reacts with several targets. We have investigated a possible correlation between melanin-type and the antioxidant defense system after UV, focusing on the activities of superoxide dismutase and catalase, which correlated with the phototype of epidermal reconstructs. UVA was more effective than UVB in damaging these enzymatic activities, especially catalase. Furthermore, UVA irradiation induced a free-radical-mediated damage in the cells, leading to an oxidation of cell proteins. On catalase, synthetic pheomelanin amplified this effect on specific targets, such as residues of tryptophan and methionine. UVA irradiation of low phototype reconstructed epidermis and of U937 through synthetic pheomelanin induced a modification in the electrophoretic properties of native catalase, which was counteracted by histidine, a quencher of singlet oxygen. These results demonstrate that pheomelanin could act as a photosensitizing agent, following UVA irradiation, inducing charge modifications of native catalase, by a mechanism involving singlet oxygen or its downstream products. catalase cysteinyl-DOPA-melanin DOPA-melanin 2,4-dinitrophenylhydrazine histidine hydrogen peroxide l-5-hydroxytryptophan methionine l-methionine sulfoxide phosphate-buffered saline reconstructed epidermis with only keratinocytes reconstructed epidermis with keratinocytes and melanocytes from high phototype skin reconstructed epidermis with keratinocytes and melanocytes from low phototype skin reactive oxygen species superoxide dismutase l-tryptophan" @default.
• W2083007831 created "2016-06-24" @default.
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• W2083007831 date "2006-01-01" @default.
• W2083007831 modified "2023-10-12" @default.
• W2083007831 title "UVA-Induced Modification of Catalase Charge Properties in the Epidermis Is Correlated with the Skin Phototype" @default.
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• W2083007831 doi "https://doi.org/10.1038/sj.jid.5700021" @default.
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• W2083007831 hasPublicationYear "2006" @default.
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