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- W2083009436 abstract "A dengue subunit vaccine candidate was developed using a mammalian cell line continuously expressing subviral extracellular particles (EPs) of the New Guinea C (NGC) strain of dengue type 2 virus. The cell line, designated D cell line, maintained envelope (E) antigen production for at least 10 passages. The EPs contained an E protein biochemically and antigenically equivalent to authentic E produced by NGC-infected Vero cells. Two immunizations of BALB/c mice with purified EPs containing 100ng or 400ng of E induced moderate levels of neutralizing antibody and anamnestic neutralizing antibody responses were produced when these animals were challenged with dengue virus. The yield of E antigen from D cells was comparable to that from NGC-infected Vero cells. When D cells were transfected with the anti-apoptotic bcl-2 gene, the E antigen release increased approximately two-fold. These results indicate that D cell EPs are a promising non-infectious vaccine antigen for dengue." @default.
- W2083009436 created "2016-06-24" @default.
- W2083009436 creator A5025253939 @default.
- W2083009436 creator A5033234512 @default.
- W2083009436 date "2002-01-01" @default.
- W2083009436 modified "2023-10-06" @default.
- W2083009436 title "Dengue type 2 virus subviral extracellular particles produced by a stably transfected mammalian cell line and their evaluation for a subunit vaccine" @default.
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- W2083009436 doi "https://doi.org/10.1016/s0264-410x(01)00446-7" @default.
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