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- W2083019740 abstract "<h3>Background</h3> Despite their important role in cognitive function, the value of B vitamin supplementation is unknown. A systematic review of the effect of pyridoxine hydrochloride (hereinafter “vitamin B<sub>6</sub>”), cyanocobalamin or hydroxycobalamin (hereinafter “vitamin B<sub>12</sub>”), and folic acid supplementation on cognitive function was performed. <h3>Methods</h3> Literature search conducted in MEDLINE with supplemental articles from reviews and domain experts. We included English language randomized controlled trials of vitamins B<sub>6</sub>and/or B<sub>12</sub>and/or folic acid supplementation with cognitive function outcomes. <h3>Results</h3> Fourteen trials met our criteria; most were of low quality and limited applicability. Approximately 50 different cognitive function tests were assessed. Three trials of vitamin B<sub>6</sub>and 6 of vitamin B<sub>12</sub>found no effect overall in a variety of doses, routes of administration, and populations. One of 3 trials of folic acid found a benefit in cognitive function in people with cognitive impairment and low baseline serum folate levels. Six trials of combinations of the B vitamins all concluded that the interventions had no effect on cognitive function. Among 3 trials, those in the placebo arm had greater improvements in a small number of cognitive tests than participants receiving either folic acid or combination B-vitamin supplements. The evidence was limited by a sparsity of studies, small sample size, heterogeneity in outcomes, and a lack of studies that evaluated symptoms or clinical outcomes. <h3>Conclusion</h3> The evidence does not yet provide adequate evidence of an effect of vitamin B<sub>6</sub>or B<sub>12</sub>or folic acid supplementation, alone or in combination, on cognitive function testing in people with either normal or impaired cognitive function." @default.
- W2083019740 created "2016-06-24" @default.
- W2083019740 creator A5000950219 @default.
- W2083019740 date "2007-01-08" @default.
- W2083019740 modified "2023-10-16" @default.
- W2083019740 title "Vitamin B6, B12, and Folic Acid Supplementation and Cognitive Function" @default.
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- W2083019740 doi "https://doi.org/10.1001/archinte.167.1.21" @default.
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