FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2083027152> ?p ?o ?g. }

• W2083027152 endingPage "479" @default.
• W2083027152 startingPage "465" @default.
• W2083027152 abstract "Despite the great progress in cardiovascular health and clinical care along with marked decline in morbidity and mortality, cardiovascular diseases remain the leading causes of death and disability in the developed world. New therapeutic approaches, targeting not only systematic but also causal dysfunction, are ultimately needed to provide a valuable alternative for treatment of complex cardiovascular diseases. In heart failure, there are currently a number of trials that have been either completed or are ongoing targeting the sarcoplasmic reticulum calcium ATPase pump (SERCA2a) gene transfer in the context of heart failure. Recently, a phase 2 trial was completed, demonstrating safety and suggested benefit of adeno-associated virus type 1/SERCA2a gene transfer in advanced heart failure, supporting larger confirmatory trials. The experimental and clinical data suggest that, when administrated through perfusion, virus vector carrying SERCA2a can also transduce vascular endothelial and smooth muscle cells (EC and SMC) thereby improving the clinical benefit of gene therapy. Indeed, recent advances in understanding the molecular basis of vascular dysfunction point towards a reduction of sarcoplasmic reticulum Ca2+ uptake and an impairment of Ca2+ cycling in vascular EC and SMC from patients and preclinical models with cardiac diseases or with cardiovascular risk factors such as diabetes, hypercholesterolemia, coronary artery diseases, as well as other conditions such as pulmonary hypertension. In recent years, several studies have established that SERCA2a gene-based therapy could be an efficient option to treat vascular dysfunction. This review focuses on the recent finding showing the beneficial effects of SERCA2a gene transfer in vascular EC and SMC. Keywords: Cardiovascular disease, endothelial cells, gene therapy, SERCA2a, vascular smooth muscle cells." @default.
• W2083027152 created "2016-06-24" @default.
• W2083027152 creator A5002624513 @default.
• W2083027152 creator A5004010364 @default.
• W2083027152 creator A5005766947 @default.
• W2083027152 creator A5032209826 @default.
• W2083027152 creator A5042235796 @default.
• W2083027152 date "2013-07-01" @default.
• W2083027152 modified "2023-10-17" @default.
• W2083027152 title "Benefit of SERCA2a Gene Transfer to Vascular Endothelial and Smooth Muscle Cells: A New Aspect in Therapy of Cardiovascular Diseases" @default.
• W2083027152 cites W1479735302 @default.
• W2083027152 cites W1485297825 @default.
• W2083027152 cites W1486831897 @default.
• W2083027152 cites W1499927580 @default.
• W2083027152 cites W1518120013 @default.
• W2083027152 cites W1544518972 @default.
• W2083027152 cites W1569777697 @default.
• W2083027152 cites W1613210651 @default.
• W2083027152 cites W167819707 @default.
• W2083027152 cites W1731997554 @default.
• W2083027152 cites W1771949227 @default.
• W2083027152 cites W1832011285 @default.
• W2083027152 cites W1840777802 @default.
• W2083027152 cites W1964363992 @default.
• W2083027152 cites W1966922247 @default.
• W2083027152 cites W1970468800 @default.
• W2083027152 cites W1972775273 @default.
• W2083027152 cites W1975244725 @default.
• W2083027152 cites W1978593035 @default.
• W2083027152 cites W1979512764 @default.
• W2083027152 cites W1984444124 @default.
• W2083027152 cites W1988779724 @default.
• W2083027152 cites W1989144534 @default.
• W2083027152 cites W1992197079 @default.
• W2083027152 cites W1992718978 @default.
• W2083027152 cites W1994497806 @default.
• W2083027152 cites W1996637584 @default.
• W2083027152 cites W2000786270 @default.
• W2083027152 cites W2001475413 @default.
• W2083027152 cites W2002720305 @default.
• W2083027152 cites W2003444961 @default.
• W2083027152 cites W2004044410 @default.
• W2083027152 cites W2007555121 @default.
• W2083027152 cites W2012471725 @default.
• W2083027152 cites W2012605726 @default.
• W2083027152 cites W2012725313 @default.
• W2083027152 cites W2015016616 @default.
• W2083027152 cites W2019338486 @default.
• W2083027152 cites W2021847777 @default.
• W2083027152 cites W2023647145 @default.
• W2083027152 cites W2024482138 @default.
• W2083027152 cites W2024918253 @default.
• W2083027152 cites W2027711412 @default.
• W2083027152 cites W2028307206 @default.
• W2083027152 cites W2035138229 @default.
• W2083027152 cites W2035316013 @default.
• W2083027152 cites W2036920310 @default.
• W2083027152 cites W2038808768 @default.
• W2083027152 cites W2042428304 @default.
• W2083027152 cites W2043863706 @default.
• W2083027152 cites W2044734641 @default.
• W2083027152 cites W2047390408 @default.
• W2083027152 cites W2052876150 @default.
• W2083027152 cites W2055031028 @default.
• W2083027152 cites W2058994890 @default.
• W2083027152 cites W2059127706 @default.
• W2083027152 cites W2066142107 @default.
• W2083027152 cites W2066328217 @default.
• W2083027152 cites W2067514854 @default.
• W2083027152 cites W2070832223 @default.
• W2083027152 cites W2079071687 @default.
• W2083027152 cites W2079740701 @default.
• W2083027152 cites W2083161592 @default.
• W2083027152 cites W2088350356 @default.
• W2083027152 cites W2090018138 @default.
• W2083027152 cites W2091348761 @default.
• W2083027152 cites W2092197701 @default.
• W2083027152 cites W2093432780 @default.
• W2083027152 cites W2096168899 @default.
• W2083027152 cites W2097098660 @default.
• W2083027152 cites W2097264549 @default.
• W2083027152 cites W2101586949 @default.
• W2083027152 cites W2102145465 @default.
• W2083027152 cites W2103766009 @default.
• W2083027152 cites W2103966093 @default.
• W2083027152 cites W2104402415 @default.
• W2083027152 cites W2106234889 @default.
• W2083027152 cites W2106564957 @default.
• W2083027152 cites W2107590406 @default.
• W2083027152 cites W2108183974 @default.
• W2083027152 cites W2108660541 @default.
• W2083027152 cites W2112656429 @default.
• W2083027152 cites W2112696231 @default.
• W2083027152 cites W2116187804 @default.
• W2083027152 cites W2119949003 @default.
• W2083027152 cites W2120505177 @default.
• W2083027152 cites W2121822802 @default.
• W2083027152 cites W2122737708 @default.

• next