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- W2083043670 abstract "Medial temporal lobe atrophy (MTA) predicts Alzheimer's disease (AD) in subjects with mild cognitive impairment (MCI). MTA assessment may be used for the selection of MCI subjects in AD trials. There are several methods to assess MTA ranging from qualitative rating to manual volumetric measurements. Predictive accuracy may depend on the method and on whether the method requires standardisation of the scan protocol. The aim of the present study was to investigate which MTA assessment could best predict AD-type dementia in subjects with MCI in a multicentre and single-centre study. We selected subjects with MCI from 2 cohorts: the DESCRIPA multicentre study (n = 279), which used different scanners and scan protocols and a single-centre study from the VU University medical centre (n = 156), which used the same scanner and protocol. Four MRI-measures were compared: volumetric manual hippocampal measurement, volumetric automated atlas based hippocampal measurement (LEAP), qualitative visual rating, and volumetric measurement of the lateral ventricle. All volumetric measurements were corrected for intracranial volume and pooled for left and right side. Outcome was the area under the curve (AUC) of a ROC curve for predicting progression to AD-typedementia after 2 years. In the multicentre study, the AUC was 0.72 for the manual hippocampal measurement, 0.72 for the LEAP measurement, 0.67 for the qualitative rating, and 0.56 for the lateral ventricle measurement. In the single-centre study, the AUC was 0.67 for the manual hippocampal measurement, 0.69 for the LEAP measurement, 0.61 for the qualitative rating, and 0.61 for the lateral ventricle measurement. The best cut-point on the LEAP volume to predict AD-type dementia as determined by the Youden index was similar in the multicentre study (5374 mm3) and single-centre study (5431 mm3). Hippocampal volume predicts AD better than a qualitative rating or lateral ventricle volume. All measures yielded similar predictive accuracy in the multicentre and single-centre study. The LEAP measurement may be preferred in multicentre studies as it demonstrated good accuracy in discriminating between MCI progressors and non-progressors. Moreover, the measurement was stable across different cohorts, was automated, and was able to determine consistent cut points." @default.
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- W2083043670 date "2011-07-01" @default.
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- W2083043670 title "P1-072: Comparison of measurements of medial temporal lobe atrophy in the prediction of Alzheimer's Disease in subjects with MCI" @default.
- W2083043670 doi "https://doi.org/10.1016/j.jalz.2011.05.352" @default.
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