FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2083049369> ?p ?o ?g. }

• W2083049369 endingPage "397" @default.
• W2083049369 startingPage "390" @default.
• W2083049369 abstract "It is important to detect and prevent Alzheimer disease (AD) at its early stage. Constituting the early stage sign of AD, amnestic mild cognitive impairment (aMCI) has drawn much attention. Studies have shown that donepezil could reduce the AD assessment scale-cognitive subscale (ADAS-Cog) score in MCI patients and improve the patient's attention and speed of response; however, it also has many side effects. Therefore, the authors aim to explore the effects of Chinese herbal medicine for treating aMCI.To explore the clinical efficacy and safety of Chinese medicine for tonifying the kidney, and resolving phlegm and blood stasis in the treatment of aMCI.This clinical trial used randomized, double-blind, double-dummy and parallel-controlled design. According to the randomized, double-blind principle, some aMCI patients were randomly divided into Chinese medicine group and donepezil group. Other patients who did not receive any treatment were enrolled as the control. Patients in the Chinese medicine group received oral administration of Chinese medicine, 1 bag/dose, two doses per day, while patients in the donepezil group received donepezil hydrochloride, 5mg/day. Twelve weeks were allocated as the trial period.After 12 weeks, the Chinese medicine group patients, the donepezil group patients and those patients who did not receive any treatment were accessed using the scores of ADAS-Cog and mini-mental status examination (MMSE).The ADAS-Cog and MMSE scores of the Chinese medicine group and the donepezil group were both improved from baseline (P=0.001, P=0.000), but the non-treatment group showed no change from baseline (P=0.151, P=0.125); furthermore, there was no significant difference between the Chinese medicine group and the donepezil group. The attention function of the Chinese medicine group was better than baseline (P=0.015), but no change was seen in the donepezil group (P=0.085) at the 12th week. Safety data showed that the occurrence of insomnia, nausea and diarrhea was greater in the donepezil group than in the Chinese medicine group (P=0.002, P=0.005, P=0.000), and both treatments had no influence in participants' vital signs and laboratory examination results.Both Chinese medicine and donepezil can improve global cognition in patients with aMCI after 12 weeks of treatment. Chinese medicine can also improve attention function and some clinical symptoms in patients with aMCI. Furthermore, Chinese medicine is safe for aMCI patients. Further study is necessary to explore the long-term effect of Chinese medicine for aMCI." @default.
• W2083049369 created "2016-06-24" @default.
• W2083049369 creator A5015689691 @default.
• W2083049369 creator A5018098529 @default.
• W2083049369 creator A5046133736 @default.
• W2083049369 creator A5074783604 @default.
• W2083049369 date "2012-04-15" @default.
• W2083049369 modified "2023-09-25" @default.
• W2083049369 title "Effects of Chinese medicine for tonifying the kidney and resolving phlegm and blood stasis in treating patients with amnestic mild cognitive impairment: a randomized, double-blind and parallel-controlled trial" @default.
• W2083049369 cites W1574051717 @default.
• W2083049369 cites W1847168837 @default.
• W2083049369 cites W1948740236 @default.
• W2083049369 cites W1953027527 @default.
• W2083049369 cites W2004713321 @default.
• W2083049369 cites W2048302866 @default.
• W2083049369 cites W2057679568 @default.
• W2083049369 cites W2081285591 @default.
• W2083049369 cites W2084143358 @default.
• W2083049369 cites W2107820540 @default.
• W2083049369 cites W2115294836 @default.
• W2083049369 cites W2117134611 @default.
• W2083049369 cites W2128529067 @default.
• W2083049369 cites W2169008033 @default.
• W2083049369 doi "https://doi.org/10.3736/jcim20120407" @default.
• W2083049369 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22500712" @default.
• W2083049369 hasPublicationYear "2012" @default.
• W2083049369 type Work @default.
• W2083049369 sameAs 2083049369 @default.
• W2083049369 citedByCount "20" @default.
• W2083049369 countsByYear W20830493692013 @default.
• W2083049369 countsByYear W20830493692014 @default.
• W2083049369 countsByYear W20830493692015 @default.
• W2083049369 countsByYear W20830493692016 @default.
• W2083049369 countsByYear W20830493692017 @default.
• W2083049369 countsByYear W20830493692018 @default.
• W2083049369 countsByYear W20830493692019 @default.
• W2083049369 countsByYear W20830493692020 @default.
• W2083049369 countsByYear W20830493692021 @default.
• W2083049369 countsByYear W20830493692022 @default.
• W2083049369 countsByYear W20830493692023 @default.
• W2083049369 crossrefType "journal-article" @default.
• W2083049369 hasAuthorship W2083049369A5015689691 @default.
• W2083049369 hasAuthorship W2083049369A5018098529 @default.
• W2083049369 hasAuthorship W2083049369A5046133736 @default.
• W2083049369 hasAuthorship W2083049369A5074783604 @default.
• W2083049369 hasConcept C126322002 @default.
• W2083049369 hasConcept C142724271 @default.
• W2083049369 hasConcept C168563851 @default.
• W2083049369 hasConcept C188947578 @default.
• W2083049369 hasConcept C204787440 @default.
• W2083049369 hasConcept C2776379591 @default.
• W2083049369 hasConcept C2778731716 @default.
• W2083049369 hasConcept C2779134260 @default.
• W2083049369 hasConcept C2779483572 @default.
• W2083049369 hasConcept C2780904820 @default.
• W2083049369 hasConcept C535046627 @default.
• W2083049369 hasConcept C71924100 @default.
• W2083049369 hasConceptScore W2083049369C126322002 @default.
• W2083049369 hasConceptScore W2083049369C142724271 @default.
• W2083049369 hasConceptScore W2083049369C168563851 @default.
• W2083049369 hasConceptScore W2083049369C188947578 @default.
• W2083049369 hasConceptScore W2083049369C204787440 @default.
• W2083049369 hasConceptScore W2083049369C2776379591 @default.
• W2083049369 hasConceptScore W2083049369C2778731716 @default.
• W2083049369 hasConceptScore W2083049369C2779134260 @default.
• W2083049369 hasConceptScore W2083049369C2779483572 @default.
• W2083049369 hasConceptScore W2083049369C2780904820 @default.
• W2083049369 hasConceptScore W2083049369C535046627 @default.
• W2083049369 hasConceptScore W2083049369C71924100 @default.
• W2083049369 hasIssue "4" @default.
• W2083049369 hasLocation W20830493691 @default.
• W2083049369 hasLocation W20830493692 @default.
• W2083049369 hasOpenAccess W2083049369 @default.
• W2083049369 hasPrimaryLocation W20830493691 @default.
• W2083049369 hasRelatedWork W2083049369 @default.
• W2083049369 hasRelatedWork W2351802882 @default.
• W2083049369 hasRelatedWork W2355192832 @default.
• W2083049369 hasRelatedWork W2359674360 @default.
• W2083049369 hasRelatedWork W2370826507 @default.
• W2083049369 hasRelatedWork W2378211244 @default.
• W2083049369 hasRelatedWork W2386372543 @default.
• W2083049369 hasRelatedWork W2388920379 @default.
• W2083049369 hasRelatedWork W2392817411 @default.
• W2083049369 hasRelatedWork W3031128336 @default.
• W2083049369 hasVolume "10" @default.
• W2083049369 isParatext "false" @default.
• W2083049369 isRetracted "false" @default.
• W2083049369 magId "2083049369" @default.
• W2083049369 workType "article" @default.