Matches in SemOpenAlex for { <https://semopenalex.org/work/W2083057314> ?p ?o ?g. }
- W2083057314 endingPage "225" @default.
- W2083057314 startingPage "221" @default.
- W2083057314 abstract "Leukotrienes may mediate bronchoconstriction in asthma. Cysteinyl leukotriene production rises in vivo after allergen challenge, but few reports describe leukotriene concentrations in clinical asthma or in children. Using high performance liquid chromatography/radioimmunoassay, plasma and urinary leukotrienes in asthmatic children (aged 5-10 years) were measured during an acute exacerbation (peak expiratory flow (PEF) < 65%, n = 10) and one month later (PEF 74-169%, n = 9), and in non-atopic normal children (aged 1.3-13.2 years). In the asthmatics, geometric mean (95% confidence interval) plasma leukotriene B4 (LTB4) was 746 pg/ml (398 to 1403) acutely and 1026 pg/ml (662 to 1593) in remission, compared with 369 pg/ml (167 to 728) in the normal children (n = 14). Plasma cysteinyl leukotrienes were low or undetectable, but urinary leukotriene E4 (LTE4) was higher in the asthmatics during an acute episode (210 pmol/mmol creatinine, 101 to 454) and at follow up (179 pmol/mmol, 110 to 293), compared with the normal children (98 pmol/mmol, 81 to 118, n = 41). This persistent increase in plasma LTB4 and urinary LTE4 concentrations one month after a severe asthmatic episode suggests leukotriene production is related to chronic inflammation rather than to acute bronchoconstriction." @default.
- W2083057314 created "2016-06-24" @default.
- W2083057314 creator A5054040562 @default.
- W2083057314 creator A5069166441 @default.
- W2083057314 creator A5075226181 @default.
- W2083057314 creator A5076246865 @default.
- W2083057314 date "1995-09-01" @default.
- W2083057314 modified "2023-10-03" @default.
- W2083057314 title "Persistent increase in plasma and urinary leukotrienes after acute asthma." @default.
- W2083057314 cites W1603889483 @default.
- W2083057314 cites W1900718892 @default.
- W2083057314 cites W1965765359 @default.
- W2083057314 cites W1968661657 @default.
- W2083057314 cites W1968723792 @default.
- W2083057314 cites W1971569966 @default.
- W2083057314 cites W1973578823 @default.
- W2083057314 cites W1979513219 @default.
- W2083057314 cites W1981211197 @default.
- W2083057314 cites W1981818027 @default.
- W2083057314 cites W1995220193 @default.
- W2083057314 cites W1996220664 @default.
- W2083057314 cites W1997269409 @default.
- W2083057314 cites W2004459162 @default.
- W2083057314 cites W2007323623 @default.
- W2083057314 cites W2022724314 @default.
- W2083057314 cites W2032353293 @default.
- W2083057314 cites W2035277497 @default.
- W2083057314 cites W2040961159 @default.
- W2083057314 cites W2043008520 @default.
- W2083057314 cites W2044880620 @default.
- W2083057314 cites W2044896616 @default.
- W2083057314 cites W2053939881 @default.
- W2083057314 cites W2058534254 @default.
- W2083057314 cites W2065283934 @default.
- W2083057314 cites W2066950125 @default.
- W2083057314 cites W2070040208 @default.
- W2083057314 cites W2079336364 @default.
- W2083057314 cites W2088724274 @default.
- W2083057314 cites W2092100550 @default.
- W2083057314 cites W2092887324 @default.
- W2083057314 cites W2103847319 @default.
- W2083057314 cites W2128157941 @default.
- W2083057314 cites W2395087307 @default.
- W2083057314 cites W2402677767 @default.
- W2083057314 cites W2410510205 @default.
- W2083057314 cites W2411143712 @default.
- W2083057314 cites W2414631092 @default.
- W2083057314 cites W2460068008 @default.
- W2083057314 cites W2473841039 @default.
- W2083057314 cites W4251280815 @default.
- W2083057314 doi "https://doi.org/10.1136/adc.73.3.221" @default.
- W2083057314 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1511288" @default.
- W2083057314 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7492159" @default.
- W2083057314 hasPublicationYear "1995" @default.
- W2083057314 type Work @default.
- W2083057314 sameAs 2083057314 @default.
- W2083057314 citedByCount "107" @default.
- W2083057314 countsByYear W20830573142012 @default.
- W2083057314 countsByYear W20830573142013 @default.
- W2083057314 countsByYear W20830573142014 @default.
- W2083057314 countsByYear W20830573142015 @default.
- W2083057314 countsByYear W20830573142017 @default.
- W2083057314 countsByYear W20830573142019 @default.
- W2083057314 countsByYear W20830573142020 @default.
- W2083057314 countsByYear W20830573142021 @default.
- W2083057314 countsByYear W20830573142022 @default.
- W2083057314 countsByYear W20830573142023 @default.
- W2083057314 crossrefType "journal-article" @default.
- W2083057314 hasAuthorship W2083057314A5054040562 @default.
- W2083057314 hasAuthorship W2083057314A5069166441 @default.
- W2083057314 hasAuthorship W2083057314A5075226181 @default.
- W2083057314 hasAuthorship W2083057314A5076246865 @default.
- W2083057314 hasBestOaLocation W20830573141 @default.
- W2083057314 hasConcept C126322002 @default.
- W2083057314 hasConcept C134018914 @default.
- W2083057314 hasConcept C203014093 @default.
- W2083057314 hasConcept C2776042228 @default.
- W2083057314 hasConcept C2776452501 @default.
- W2083057314 hasConcept C2777014857 @default.
- W2083057314 hasConcept C2777242621 @default.
- W2083057314 hasConcept C2778053663 @default.
- W2083057314 hasConcept C2780769369 @default.
- W2083057314 hasConcept C71924100 @default.
- W2083057314 hasConcept C77411442 @default.
- W2083057314 hasConceptScore W2083057314C126322002 @default.
- W2083057314 hasConceptScore W2083057314C134018914 @default.
- W2083057314 hasConceptScore W2083057314C203014093 @default.
- W2083057314 hasConceptScore W2083057314C2776042228 @default.
- W2083057314 hasConceptScore W2083057314C2776452501 @default.
- W2083057314 hasConceptScore W2083057314C2777014857 @default.
- W2083057314 hasConceptScore W2083057314C2777242621 @default.
- W2083057314 hasConceptScore W2083057314C2778053663 @default.
- W2083057314 hasConceptScore W2083057314C2780769369 @default.
- W2083057314 hasConceptScore W2083057314C71924100 @default.
- W2083057314 hasConceptScore W2083057314C77411442 @default.
- W2083057314 hasIssue "3" @default.
- W2083057314 hasLocation W20830573141 @default.
- W2083057314 hasLocation W20830573142 @default.