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- W2083067006 abstract "Based on amino acid sequence comparisons, Pax1 and Pax9 genes are considered to form a subgroup of vertebrate Pax genes. We show here that the gene structures of mouse Pax1, human PAX9 genes are similar to that of a single Pax1/9 related gene in Branchiostoma lanceolatum, AmphiPax1. This supports the hypothesis that Pax1 and Pax9 genes were derived from a single ancestral gene. A refined protein alignment of AmphiPax1, mouse Pax1 and human PAX9 proteins based on the determined exon boundaries indicates that sequence divergence at the C-termini may be related to the unique functions of the Pax1 and Pax9 genes in vertebrates. AmphiPax1 is expressed in adult amphioxus in the pharyngeal endoderm." @default.
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- W2083067006 date "2000-07-01" @default.
- W2083067006 modified "2023-09-24" @default.
- W2083067006 title "Evolutionary conservation of gene structures of the Pax1/9 gene family" @default.
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- W2083067006 doi "https://doi.org/10.1016/s0167-4781(00)00130-5" @default.
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