FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2083079076> ?p ?o ?g. }

• W2083079076 endingPage "935" @default.
• W2083079076 startingPage "923" @default.
• W2083079076 abstract "It is not known whether or not epithelial progenitors of the pyloric antrum are involved in gastric carcinogenesis. Normally, these progenitors give rise to two main cell lineages: pit and gland mucous cells. This study was designed to examine the changes that occur in pyloric antral mucous cell lineages and their progenitors during development of gastric adenoma and carcinoma in trefoil factor 1 (TFF1) knockout mice.Pyloric antral mucosal tissues of TFF1 knockout mice at ages from 3 days to 17 months were processed for histochemical analysis using Ulex europaeus and Grifforia simplifolica lectins as markers for pit and gland mucous cells, respectively. The dividing epithelial progenitors were identified by using immunohistochemical and electron microscopy techniques.TFF1 loss was associated with amplification of both mucus-secreting pit and gland cells. Both lectins examined bound not only to mature mucous cells, but also to most of epithelial progenitors which gradually amplified with age and frequently were seen in mitosis. Analysis of 12- to 17-month-old TFF1-deficient stomachs revealed occasional groups of poorly differentiated mucosal cells with features similar to those of epithelial progenitors (or stem cells), in the basal portion of the antral mucosa. These cells eventually invaded the muscularis mucosa while maintaining some capacity to differentiate.This study shows that the progenitors of pit and gland mucous cells contribute to gastric carcinogenesis in the pyloric antrum of TFF1 knockout mice, strongly supporting the concept of stem cell origin of cancer." @default.
• W2083079076 created "2016-06-24" @default.
• W2083079076 creator A5012068944 @default.
• W2083079076 creator A5021887762 @default.
• W2083079076 creator A5046035933 @default.
• W2083079076 date "2008-11-18" @default.
• W2083079076 modified "2023-10-18" @default.
• W2083079076 title "Amplification and invasiveness of epithelial progenitors during gastric carcinogenesis in trefoil factor 1 knockout mice" @default.
• W2083079076 cites W1503849321 @default.
• W2083079076 cites W1571511334 @default.
• W2083079076 cites W1962773487 @default.
• W2083079076 cites W1967679084 @default.
• W2083079076 cites W1978393485 @default.
• W2083079076 cites W1979484504 @default.
• W2083079076 cites W1982282184 @default.
• W2083079076 cites W1985292219 @default.
• W2083079076 cites W1994374831 @default.
• W2083079076 cites W1998967355 @default.
• W2083079076 cites W1999223850 @default.
• W2083079076 cites W1999738788 @default.
• W2083079076 cites W2003605454 @default.
• W2083079076 cites W2009343546 @default.
• W2083079076 cites W2022208541 @default.
• W2083079076 cites W2023026216 @default.
• W2083079076 cites W2046645497 @default.
• W2083079076 cites W2059360328 @default.
• W2083079076 cites W2085904237 @default.
• W2083079076 cites W2088575158 @default.
• W2083079076 cites W2107774298 @default.
• W2083079076 cites W2114898676 @default.
• W2083079076 cites W2125619663 @default.
• W2083079076 cites W2127248987 @default.
• W2083079076 cites W2135169290 @default.
• W2083079076 cites W2145952115 @default.
• W2083079076 cites W2152345385 @default.
• W2083079076 cites W2153718909 @default.
• W2083079076 cites W2171217269 @default.
• W2083079076 cites W2182858288 @default.
• W2083079076 cites W2466618954 @default.
• W2083079076 cites W4211113621 @default.
• W2083079076 cites W4237346226 @default.
• W2083079076 doi "https://doi.org/10.1111/j.1365-2184.2008.00562.x" @default.
• W2083079076 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6496233" @default.
• W2083079076 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19040570" @default.
• W2083079076 hasPublicationYear "2008" @default.
• W2083079076 type Work @default.
• W2083079076 sameAs 2083079076 @default.
• W2083079076 citedByCount "26" @default.
• W2083079076 countsByYear W20830790762012 @default.
• W2083079076 countsByYear W20830790762013 @default.
• W2083079076 countsByYear W20830790762014 @default.
• W2083079076 countsByYear W20830790762016 @default.
• W2083079076 countsByYear W20830790762019 @default.
• W2083079076 countsByYear W20830790762020 @default.
• W2083079076 countsByYear W20830790762021 @default.
• W2083079076 countsByYear W20830790762022 @default.
• W2083079076 countsByYear W20830790762023 @default.
• W2083079076 crossrefType "journal-article" @default.
• W2083079076 hasAuthorship W2083079076A5012068944 @default.
• W2083079076 hasAuthorship W2083079076A5021887762 @default.
• W2083079076 hasAuthorship W2083079076A5046035933 @default.
• W2083079076 hasBestOaLocation W20830790762 @default.
• W2083079076 hasConcept C121608353 @default.
• W2083079076 hasConcept C131253125 @default.
• W2083079076 hasConcept C142724271 @default.
• W2083079076 hasConcept C170493617 @default.
• W2083079076 hasConcept C182704531 @default.
• W2083079076 hasConcept C18903297 @default.
• W2083079076 hasConcept C201750760 @default.
• W2083079076 hasConcept C2777312293 @default.
• W2083079076 hasConcept C2779422922 @default.
• W2083079076 hasConcept C2781443798 @default.
• W2083079076 hasConcept C28328180 @default.
• W2083079076 hasConcept C2910480513 @default.
• W2083079076 hasConcept C529295009 @default.
• W2083079076 hasConcept C54355233 @default.
• W2083079076 hasConcept C55493867 @default.
• W2083079076 hasConcept C555283112 @default.
• W2083079076 hasConcept C71924100 @default.
• W2083079076 hasConcept C86803240 @default.
• W2083079076 hasConcept C90378955 @default.
• W2083079076 hasConcept C95444343 @default.
• W2083079076 hasConceptScore W2083079076C121608353 @default.
• W2083079076 hasConceptScore W2083079076C131253125 @default.
• W2083079076 hasConceptScore W2083079076C142724271 @default.
• W2083079076 hasConceptScore W2083079076C170493617 @default.
• W2083079076 hasConceptScore W2083079076C182704531 @default.
• W2083079076 hasConceptScore W2083079076C18903297 @default.
• W2083079076 hasConceptScore W2083079076C201750760 @default.
• W2083079076 hasConceptScore W2083079076C2777312293 @default.
• W2083079076 hasConceptScore W2083079076C2779422922 @default.
• W2083079076 hasConceptScore W2083079076C2781443798 @default.
• W2083079076 hasConceptScore W2083079076C28328180 @default.
• W2083079076 hasConceptScore W2083079076C2910480513 @default.
• W2083079076 hasConceptScore W2083079076C529295009 @default.
• W2083079076 hasConceptScore W2083079076C54355233 @default.
• W2083079076 hasConceptScore W2083079076C55493867 @default.
• W2083079076 hasConceptScore W2083079076C555283112 @default.

• next