FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2083081144> ?p ?o ?g. }

• W2083081144 endingPage "862" @default.
• W2083081144 startingPage "851" @default.
• W2083081144 abstract "Abstract Glioblastoma multiforme (GBM) are highly proliferative tumors currently treated by surgical removal, followed by radiotherapy and chemotherapy, which are counteracted by intratumoral hypoxia. Here we exploited image guided surgery to sample multiple intratumoral areas to define potential cellular heterogeneity in correlation to the oxygen tension gradient within the GBM mass. Our results indicate that more immature cells are localized in the inner core and in the intermediate layer of the tumor mass, whereas more committed cells, expressing glial fibrillary acidic protein and β-III-tubulin, are distributed along the peripheral and neo-vascularized area, where Smad1/5/8 and Stat3 result to be activated. Moreover, GBM stem cells, identified with the stem cell marker CD133, express high level of DNA repair protein O6-methylguanine-DNA-methyltransferase (MGMT) known to be involved in chemotherapy resistance and highly expressed in the inner core of the tumor mass. Importantly, these cells and, particularly, CD133+ cells result to be resistant to temozolomide (TMZ), the most used oral alkylating agent for the treatment of GBM, which specifically causes apoptosis only in GBM cells derived from the peripheral layer of the tumor mass. These results indicate a correlation between the intratumoral hypoxic gradient, the tumor cell phenotype, and the tumor resistance to chemotherapy leading to a novel concentric model of tumor stem cell niche, which may be useful to define the real localization of the chemoresistant GBM tumor cells in order to design more effective treatment strategies." @default.
• W2083081144 created "2016-06-24" @default.
• W2083081144 creator A5001649298 @default.
• W2083081144 creator A5010155982 @default.
• W2083081144 creator A5021966173 @default.
• W2083081144 creator A5032067039 @default.
• W2083081144 creator A5051460984 @default.
• W2083081144 creator A5051981929 @default.
• W2083081144 creator A5052223562 @default.
• W2083081144 creator A5060611622 @default.
• W2083081144 creator A5062104854 @default.
• W2083081144 creator A5065260097 @default.
• W2083081144 date "2010-03-22" @default.
• W2083081144 modified "2023-10-11" @default.
• W2083081144 title "Intratumoral Hypoxic Gradient Drives Stem Cells Distribution and MGMT Expression in Glioblastoma" @default.
• W2083081144 cites W1970832400 @default.
• W2083081144 cites W1979964850 @default.
• W2083081144 cites W2001544973 @default.
• W2083081144 cites W2013792040 @default.
• W2083081144 cites W2017883800 @default.
• W2083081144 cites W2018590891 @default.
• W2083081144 cites W2018607339 @default.
• W2083081144 cites W2024466310 @default.
• W2083081144 cites W2026226751 @default.
• W2083081144 cites W2030251237 @default.
• W2083081144 cites W2037715584 @default.
• W2083081144 cites W2039075677 @default.
• W2083081144 cites W2040385253 @default.
• W2083081144 cites W2044892825 @default.
• W2083081144 cites W2046371943 @default.
• W2083081144 cites W2049607351 @default.
• W2083081144 cites W2051588629 @default.
• W2083081144 cites W2057793212 @default.
• W2083081144 cites W2069415914 @default.
• W2083081144 cites W2075448429 @default.
• W2083081144 cites W2086833517 @default.
• W2083081144 cites W2090395289 @default.
• W2083081144 cites W2102085111 @default.
• W2083081144 cites W2104551938 @default.
• W2083081144 cites W2105100844 @default.
• W2083081144 cites W2107749175 @default.
• W2083081144 cites W2110450508 @default.
• W2083081144 cites W2119793842 @default.
• W2083081144 cites W2121625674 @default.
• W2083081144 cites W2123509170 @default.
• W2083081144 cites W2124078079 @default.
• W2083081144 cites W2131981377 @default.
• W2083081144 cites W2144954025 @default.
• W2083081144 cites W2151856174 @default.
• W2083081144 cites W2152387543 @default.
• W2083081144 cites W2155524619 @default.
• W2083081144 cites W2157962535 @default.
• W2083081144 cites W2160382843 @default.
• W2083081144 cites W2167414381 @default.
• W2083081144 cites W2001291749 @default.
• W2083081144 doi "https://doi.org/10.1002/stem.415" @default.
• W2083081144 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20309962" @default.
• W2083081144 hasPublicationYear "2010" @default.
• W2083081144 type Work @default.
• W2083081144 sameAs 2083081144 @default.
• W2083081144 citedByCount "234" @default.
• W2083081144 countsByYear W20830811442012 @default.
• W2083081144 countsByYear W20830811442013 @default.
• W2083081144 countsByYear W20830811442014 @default.
• W2083081144 countsByYear W20830811442015 @default.
• W2083081144 countsByYear W20830811442016 @default.
• W2083081144 countsByYear W20830811442017 @default.
• W2083081144 countsByYear W20830811442018 @default.
• W2083081144 countsByYear W20830811442019 @default.
• W2083081144 countsByYear W20830811442020 @default.
• W2083081144 countsByYear W20830811442021 @default.
• W2083081144 countsByYear W20830811442022 @default.
• W2083081144 countsByYear W20830811442023 @default.
• W2083081144 crossrefType "journal-article" @default.
• W2083081144 hasAuthorship W2083081144A5001649298 @default.
• W2083081144 hasAuthorship W2083081144A5010155982 @default.
• W2083081144 hasAuthorship W2083081144A5021966173 @default.
• W2083081144 hasAuthorship W2083081144A5032067039 @default.
• W2083081144 hasAuthorship W2083081144A5051460984 @default.
• W2083081144 hasAuthorship W2083081144A5051981929 @default.
• W2083081144 hasAuthorship W2083081144A5052223562 @default.
• W2083081144 hasAuthorship W2083081144A5060611622 @default.
• W2083081144 hasAuthorship W2083081144A5062104854 @default.
• W2083081144 hasAuthorship W2083081144A5065260097 @default.
• W2083081144 hasBestOaLocation W20830811441 @default.
• W2083081144 hasConcept C136302470 @default.
• W2083081144 hasConcept C142724271 @default.
• W2083081144 hasConcept C203014093 @default.
• W2083081144 hasConcept C204232928 @default.
• W2083081144 hasConcept C2777389519 @default.
• W2083081144 hasConcept C2778227246 @default.
• W2083081144 hasConcept C2780495277 @default.
• W2083081144 hasConcept C28328180 @default.
• W2083081144 hasConcept C502942594 @default.
• W2083081144 hasConcept C55427017 @default.
• W2083081144 hasConcept C71924100 @default.
• W2083081144 hasConcept C86803240 @default.
• W2083081144 hasConcept C95444343 @default.

• next