Matches in SemOpenAlex for { <https://semopenalex.org/work/W2083088625> ?p ?o ?g. }
- W2083088625 abstract "N-myc downstream-regulated gene 1 (NDRG1) mutations cause Charcot-Marie-Tooth disease type 4D (CMT4D). However, the cellular function of NDRG1 and how it causes CMT4D are poorly understood. We report that NDRG1 silencing in epithelial cells results in decreased uptake of low-density lipoprotein (LDL) due to reduced LDL receptor (LDLR) abundance at the plasma membrane. This is accompanied by the accumulation of LDLR in enlarged EEA1-positive endosomes that contain numerous intraluminal vesicles and sequester ceramide. Concomitantly, LDLR ubiquitylation is increased but its degradation is reduced and ESCRT (endosomal sorting complex required for transport) proteins are downregulated. Co-depletion of IDOL (inducible degrader of the LDLR), which ubiquitylates the LDLR and promotes its degradation, rescues plasma membrane LDLR levels and LDL uptake. In murine oligodendrocytes, Ndrg1 silencing not only results in reduced LDL uptake but also in downregulation of the oligodendrocyte differentiation factor Olig2. Both phenotypes are rescued by co-silencing of Idol, suggesting that ligand uptake through LDLR family members controls oligodendrocyte differentiation. These findings identify NDRG1 as a novel regulator of multivesicular body formation and endosomal LDLR trafficking. The deficiency of functional NDRG1 in CMT4D might impair lipid processing and differentiation of myelinating cells." @default.
- W2083088625 created "2016-06-24" @default.
- W2083088625 creator A5004530946 @default.
- W2083088625 creator A5005612503 @default.
- W2083088625 creator A5026423174 @default.
- W2083088625 creator A5046597133 @default.
- W2083088625 creator A5047655780 @default.
- W2083088625 creator A5068795367 @default.
- W2083088625 creator A5069782141 @default.
- W2083088625 creator A5081860537 @default.
- W2083088625 creator A5087036071 @default.
- W2083088625 date "2013-01-01" @default.
- W2083088625 modified "2023-09-25" @default.
- W2083088625 title "NDRG1 functions in LDL receptor trafficking by regulating endosomal recycling and degradation" @default.
- W2083088625 cites W1546031868 @default.
- W2083088625 cites W1551789416 @default.
- W2083088625 cites W1889741616 @default.
- W2083088625 cites W1963967499 @default.
- W2083088625 cites W1967197219 @default.
- W2083088625 cites W1970726307 @default.
- W2083088625 cites W1971598818 @default.
- W2083088625 cites W1975189319 @default.
- W2083088625 cites W1976220554 @default.
- W2083088625 cites W1981443842 @default.
- W2083088625 cites W1984590580 @default.
- W2083088625 cites W1988086083 @default.
- W2083088625 cites W1991669847 @default.
- W2083088625 cites W1991678197 @default.
- W2083088625 cites W1998079639 @default.
- W2083088625 cites W1998444616 @default.
- W2083088625 cites W2001609281 @default.
- W2083088625 cites W2005868265 @default.
- W2083088625 cites W2013341229 @default.
- W2083088625 cites W2014626499 @default.
- W2083088625 cites W2025871861 @default.
- W2083088625 cites W2027111525 @default.
- W2083088625 cites W2030341081 @default.
- W2083088625 cites W2031788993 @default.
- W2083088625 cites W2034947351 @default.
- W2083088625 cites W2038446576 @default.
- W2083088625 cites W2045083711 @default.
- W2083088625 cites W2046887163 @default.
- W2083088625 cites W2049369927 @default.
- W2083088625 cites W2051338141 @default.
- W2083088625 cites W2052855401 @default.
- W2083088625 cites W2060972405 @default.
- W2083088625 cites W2067061663 @default.
- W2083088625 cites W2072024204 @default.
- W2083088625 cites W2073124059 @default.
- W2083088625 cites W2073222527 @default.
- W2083088625 cites W2082011949 @default.
- W2083088625 cites W2093675497 @default.
- W2083088625 cites W2096330132 @default.
- W2083088625 cites W2096379390 @default.
- W2083088625 cites W2102400397 @default.
- W2083088625 cites W2104520484 @default.
- W2083088625 cites W2109691647 @default.
- W2083088625 cites W2110543371 @default.
- W2083088625 cites W2119764013 @default.
- W2083088625 cites W2124940469 @default.
- W2083088625 cites W2127791131 @default.
- W2083088625 cites W2130448025 @default.
- W2083088625 cites W2132206752 @default.
- W2083088625 cites W2134893181 @default.
- W2083088625 cites W2137053978 @default.
- W2083088625 cites W2144795546 @default.
- W2083088625 cites W2145893531 @default.
- W2083088625 cites W2148553396 @default.
- W2083088625 cites W2149360857 @default.
- W2083088625 cites W2150495344 @default.
- W2083088625 cites W2150697625 @default.
- W2083088625 cites W2152311269 @default.
- W2083088625 cites W2157159684 @default.
- W2083088625 cites W2160245024 @default.
- W2083088625 cites W2164276007 @default.
- W2083088625 cites W2168016965 @default.
- W2083088625 cites W2169559002 @default.
- W2083088625 cites W2312836697 @default.
- W2083088625 cites W265817920 @default.
- W2083088625 doi "https://doi.org/10.1242/jcs.128132" @default.
- W2083088625 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23813961" @default.
- W2083088625 hasPublicationYear "2013" @default.
- W2083088625 type Work @default.
- W2083088625 sameAs 2083088625 @default.
- W2083088625 citedByCount "59" @default.
- W2083088625 countsByYear W20830886252014 @default.
- W2083088625 countsByYear W20830886252015 @default.
- W2083088625 countsByYear W20830886252016 @default.
- W2083088625 countsByYear W20830886252017 @default.
- W2083088625 countsByYear W20830886252018 @default.
- W2083088625 countsByYear W20830886252019 @default.
- W2083088625 countsByYear W20830886252020 @default.
- W2083088625 countsByYear W20830886252021 @default.
- W2083088625 countsByYear W20830886252022 @default.
- W2083088625 countsByYear W20830886252023 @default.
- W2083088625 crossrefType "journal-article" @default.
- W2083088625 hasAuthorship W2083088625A5004530946 @default.
- W2083088625 hasAuthorship W2083088625A5005612503 @default.
- W2083088625 hasAuthorship W2083088625A5026423174 @default.
- W2083088625 hasAuthorship W2083088625A5046597133 @default.