FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2083089749> ?p ?o ?g. }

• W2083089749 endingPage "90" @default.
• W2083089749 startingPage "81" @default.
• W2083089749 abstract "<i>Background/Aims:</i> Raised cytokine levels and a hypoperfusion-associated decrease in glomerular filtration rate (GFR) are hallmarks of the genesis of septic acute renal failure (ARF). Therefore, anti-inflammatory as well as renal vasodilating therapeutic strategies may afford renal protection during septic ARF. The present study was designed to determine the effects of administration of urodilatin, pentoxifylline and theophylline to improve renal function in an ex-vivo model of ‘septic renal injury’. <i>Methods:</i> Eight series of experiments were performed: no intervention, perfusion with a suspension containing <i>Escherichia coli </i>bacteria (strain 536/21); <i>E. coli </i>+ 10 μg/l urodilatin, <i>E. coli </i>+ 20 μg/l urodilatin, <i>E. coli</i> + 100 μ<i>M</i> theophylline, <i>E. coli </i>+ 100 μ<i>M</i> pentoxifylline and <i>E. coli </i>+ URO 20 μg/l given 90 min after start of perfusion. Renal vascular and glomerular functional parameters as well as TNF-α release were analyzed up to 180 min. <i>Results:</i> Perfusion with <i>E. coli </i>caused an acute deterioration of renal vascular and glomerular function. URO 20 μg/l and PTX decreased renal vascular resistance (RVR) from 83.7 ± 18.4 to 9.2 ± 1.1 and 8.6 ± 2.2 mm Hg/ml/min/g kidney and increased renal perfusion flow rate (PFR) from 8.2 ± 1.5 to 14.6 ± 0.8 and 14.1 ± 2.2 ml/min/g kidney. As a result, GFR improved from 102.1 ± 15.6 to 442 ± 48.3 and 525.8 ± 57 μl/min/g kidney during treatment with URO 20 μg/l and PTX, respectively. Renal TNF-α release was significantly reduced by URO 20 μg/l (from 178 ± 23 to 45.2 ± 2 and 47 ± 3 pg/ml) in the <i>E. coli </i>+ URO 20 μg/l and by PTX in the <i>E. coli </i>+ PTX group if added to the perfusion medium upon start of perfusion. Interestingly, URO 20 μg/l also decreased RVR significantly from 62.2 ± 6.1 to 35.9 ± 6.0 mm Hg/ml/min/g kidney, improved PFR from 5.4 ± 1.0 to 8.7 ± 1.0 ml/min/g kidney, increased GFR from 160 ± 43.3 to 280.7 ± 27.9 μl/min/g kidney, and decreased TNF-α release to 122 ± 18 pg/ml if applied 90 min after induction of septic ARF. In contrast, URO 10 μg/l did not significantly increase urine flow and did not appear to significantly improve renal perfusion. Theophylline showed no beneficial effects at all. <i>Conclusion:</i> This suggests that urodilatin and pentoxifylline might be useful to protect renal function if given before a septic renal insult. Additionally, treatment with urodilatin is capable of restoring renal function in early Gram-negative sepsis-induced ARF even if given after the septic insult." @default.
• W2083089749 created "2016-06-24" @default.
• W2083089749 creator A5015846555 @default.
• W2083089749 creator A5020437320 @default.
• W2083089749 creator A5039273305 @default.
• W2083089749 creator A5050239956 @default.
• W2083089749 creator A5070261765 @default.
• W2083089749 creator A5091789189 @default.
• W2083089749 date "2009-01-01" @default.
• W2083089749 modified "2023-09-25" @default.
• W2083089749 title "Urodilatin and Pentoxifylline Prevent the Early Onset of <i>Escherichia coli</i>-Induced Acute Renal Failure in a Model of Isolated Perfused Rat Kidney" @default.
• W2083089749 cites W120020303 @default.
• W2083089749 cites W144271650 @default.
• W2083089749 cites W1513845930 @default.
• W2083089749 cites W1572450332 @default.
• W2083089749 cites W174365962 @default.
• W2083089749 cites W1775749144 @default.
• W2083089749 cites W1780157740 @default.
• W2083089749 cites W1932228499 @default.
• W2083089749 cites W1965293177 @default.
• W2083089749 cites W1968154729 @default.
• W2083089749 cites W1975684819 @default.
• W2083089749 cites W1977589318 @default.
• W2083089749 cites W1989999753 @default.
• W2083089749 cites W1992173992 @default.
• W2083089749 cites W1995259066 @default.
• W2083089749 cites W1995624301 @default.
• W2083089749 cites W1999651734 @default.
• W2083089749 cites W2003139282 @default.
• W2083089749 cites W2022166563 @default.
• W2083089749 cites W2027505646 @default.
• W2083089749 cites W2033634651 @default.
• W2083089749 cites W2034570138 @default.
• W2083089749 cites W2034674492 @default.
• W2083089749 cites W2037105658 @default.
• W2083089749 cites W2038266629 @default.
• W2083089749 cites W2048722868 @default.
• W2083089749 cites W2049660352 @default.
• W2083089749 cites W2049927822 @default.
• W2083089749 cites W2050227094 @default.
• W2083089749 cites W2053827071 @default.
• W2083089749 cites W2065578442 @default.
• W2083089749 cites W2074899541 @default.
• W2083089749 cites W2076119153 @default.
• W2083089749 cites W2079276600 @default.
• W2083089749 cites W2080017198 @default.
• W2083089749 cites W2084384805 @default.
• W2083089749 cites W2105230881 @default.
• W2083089749 cites W2111943085 @default.
• W2083089749 cites W2121778533 @default.
• W2083089749 cites W2123151246 @default.
• W2083089749 cites W2130043494 @default.
• W2083089749 cites W2136270624 @default.
• W2083089749 cites W2142068477 @default.
• W2083089749 cites W2145577370 @default.
• W2083089749 cites W2151517451 @default.
• W2083089749 cites W2152987299 @default.
• W2083089749 cites W2154986839 @default.
• W2083089749 cites W2170568009 @default.
• W2083089749 cites W2302448715 @default.
• W2083089749 cites W2407023198 @default.
• W2083089749 cites W2407581699 @default.
• W2083089749 cites W2417884624 @default.
• W2083089749 cites W2441226570 @default.
• W2083089749 cites W7161174 @default.
• W2083089749 doi "https://doi.org/10.1159/000209378" @default.
• W2083089749 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19321979" @default.
• W2083089749 hasPublicationYear "2009" @default.
• W2083089749 type Work @default.
• W2083089749 sameAs 2083089749 @default.
• W2083089749 citedByCount "8" @default.
• W2083089749 countsByYear W20830897492012 @default.
• W2083089749 countsByYear W20830897492016 @default.
• W2083089749 countsByYear W20830897492021 @default.
• W2083089749 crossrefType "journal-article" @default.
• W2083089749 hasAuthorship W2083089749A5015846555 @default.
• W2083089749 hasAuthorship W2083089749A5020437320 @default.
• W2083089749 hasAuthorship W2083089749A5039273305 @default.
• W2083089749 hasAuthorship W2083089749A5050239956 @default.
• W2083089749 hasAuthorship W2083089749A5070261765 @default.
• W2083089749 hasAuthorship W2083089749A5091789189 @default.
• W2083089749 hasConcept C126322002 @default.
• W2083089749 hasConcept C134018914 @default.
• W2083089749 hasConcept C142225936 @default.
• W2083089749 hasConcept C146957229 @default.
• W2083089749 hasConcept C159641895 @default.
• W2083089749 hasConcept C2780091579 @default.
• W2083089749 hasConcept C2780404050 @default.
• W2083089749 hasConcept C71924100 @default.
• W2083089749 hasConcept C98274493 @default.
• W2083089749 hasConceptScore W2083089749C126322002 @default.
• W2083089749 hasConceptScore W2083089749C134018914 @default.
• W2083089749 hasConceptScore W2083089749C142225936 @default.
• W2083089749 hasConceptScore W2083089749C146957229 @default.
• W2083089749 hasConceptScore W2083089749C159641895 @default.
• W2083089749 hasConceptScore W2083089749C2780091579 @default.
• W2083089749 hasConceptScore W2083089749C2780404050 @default.
• W2083089749 hasConceptScore W2083089749C71924100 @default.

• next