FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2083101071> ?p ?o ?g. }

• W2083101071 endingPage "615" @default.
• W2083101071 startingPage "606" @default.
• W2083101071 abstract "Abstract Objective: Reperfusion after stroke leads to infiltration of inflammatory cells into the ischemic brain. Nicotinamide adenine dinucleotide phosphate oxidase (NOX2) is a major enzyme system that generates superoxide in immune cells. We studied the effect of NOX2 derived from the immune cells in the brain and in blood cells in experimental stroke. Methods: To establish whether NOX2 plays a role in brain ischemia, strokes were created in mice, then mice were treated with the NOX2 inhibitor apocynin or vehicle and compared to mice deficient in NOX2's gp91 subunit and their wild‐type littermates. To determine whether NOX2 in circulating cells versus brain resident cells contribute to ischemic injury, bone marrow chimeras were generated by transplanting bone marrow from wild‐type or NOX2‐deficient mice into NOX2 or wild‐type hosts, respectively. Results: Apocynin and NOX2 deletion both significantly reduced infarct size, blood–brain barrier disruption, and hemorrhagic transformation of the infarcts, compared to untreated wild‐type controls. This was associated with decreased matrix metalloproteinase 9 expression and reduced loss of tight junction proteins. NOX2‐deficient mice receiving wild‐type marrow had better outcomes compared to the wild‐type mice receiving wild‐type marrow. Interestingly, wild‐type mice receiving NOX2‐deficient marrow had even smaller infarct sizes and less hemorrhage than NOX2‐deficient mice receiving wild‐type marrow. Interpretation: This indicates that NOX2, whether present in circulating cells or brain resident cells, contributes to ischemic brain injury and hemorrhage. However, NOX2 from the circulating cells contributed more to the exacerbation of stroke than that from brain resident cells. These data suggest the importance of targeting the peripheral immune system for treatment of stroke. Ann Neurol 2011;70:606–615" @default.
• W2083101071 created "2016-06-24" @default.
• W2083101071 creator A5016571028 @default.
• W2083101071 creator A5024435931 @default.
• W2083101071 creator A5031965373 @default.
• W2083101071 creator A5052775902 @default.
• W2083101071 date "2011-10-01" @default.
• W2083101071 modified "2023-10-18" @default.
• W2083101071 title "Significance of marrow-derived nicotinamide adenine dinucleotide phosphate oxidase in experimental ischemic stroke" @default.
• W2083101071 cites W1498711742 @default.
• W2083101071 cites W1965569135 @default.
• W2083101071 cites W1970935798 @default.
• W2083101071 cites W1971560806 @default.
• W2083101071 cites W1971924425 @default.
• W2083101071 cites W1973393911 @default.
• W2083101071 cites W1985094241 @default.
• W2083101071 cites W1985323628 @default.
• W2083101071 cites W1987177757 @default.
• W2083101071 cites W1995994561 @default.
• W2083101071 cites W1999288895 @default.
• W2083101071 cites W2003621176 @default.
• W2083101071 cites W2006004617 @default.
• W2083101071 cites W2010410884 @default.
• W2083101071 cites W2016198009 @default.
• W2083101071 cites W2018022526 @default.
• W2083101071 cites W2018131256 @default.
• W2083101071 cites W2027029889 @default.
• W2083101071 cites W2032423144 @default.
• W2083101071 cites W2039176792 @default.
• W2083101071 cites W2039215623 @default.
• W2083101071 cites W2060560910 @default.
• W2083101071 cites W2073923875 @default.
• W2083101071 cites W2076034559 @default.
• W2083101071 cites W2084147470 @default.
• W2083101071 cites W2096869450 @default.
• W2083101071 cites W2098137179 @default.
• W2083101071 cites W2099186103 @default.
• W2083101071 cites W2102619095 @default.
• W2083101071 cites W2110566966 @default.
• W2083101071 cites W2115334331 @default.
• W2083101071 cites W2121875633 @default.
• W2083101071 cites W2123548739 @default.
• W2083101071 cites W2145519598 @default.
• W2083101071 cites W2158571740 @default.
• W2083101071 cites W2162318134 @default.
• W2083101071 cites W2171313303 @default.
• W2083101071 cites W2324553845 @default.
• W2083101071 cites W2335021952 @default.
• W2083101071 cites W4234012993 @default.
• W2083101071 cites W4293586758 @default.
• W2083101071 doi "https://doi.org/10.1002/ana.22476" @default.
• W2083101071 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3205431" @default.
• W2083101071 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22028221" @default.
• W2083101071 hasPublicationYear "2011" @default.
• W2083101071 type Work @default.
• W2083101071 sameAs 2083101071 @default.
• W2083101071 citedByCount "63" @default.
• W2083101071 countsByYear W20831010712012 @default.
• W2083101071 countsByYear W20831010712013 @default.
• W2083101071 countsByYear W20831010712014 @default.
• W2083101071 countsByYear W20831010712015 @default.
• W2083101071 countsByYear W20831010712016 @default.
• W2083101071 countsByYear W20831010712017 @default.
• W2083101071 countsByYear W20831010712018 @default.
• W2083101071 countsByYear W20831010712019 @default.
• W2083101071 countsByYear W20831010712020 @default.
• W2083101071 countsByYear W20831010712021 @default.
• W2083101071 countsByYear W20831010712022 @default.
• W2083101071 countsByYear W20831010712023 @default.
• W2083101071 crossrefType "journal-article" @default.
• W2083101071 hasAuthorship W2083101071A5016571028 @default.
• W2083101071 hasAuthorship W2083101071A5024435931 @default.
• W2083101071 hasAuthorship W2083101071A5031965373 @default.
• W2083101071 hasAuthorship W2083101071A5052775902 @default.
• W2083101071 hasBestOaLocation W20831010712 @default.
• W2083101071 hasConcept C104317684 @default.
• W2083101071 hasConcept C126322002 @default.
• W2083101071 hasConcept C134018914 @default.
• W2083101071 hasConcept C143065580 @default.
• W2083101071 hasConcept C181199279 @default.
• W2083101071 hasConcept C203014093 @default.
• W2083101071 hasConcept C207583985 @default.
• W2083101071 hasConcept C2776151105 @default.
• W2083101071 hasConcept C2776914184 @default.
• W2083101071 hasConcept C2777209548 @default.
• W2083101071 hasConcept C2777989768 @default.
• W2083101071 hasConcept C2778402981 @default.
• W2083101071 hasConcept C2779719074 @default.
• W2083101071 hasConcept C2779830541 @default.
• W2083101071 hasConcept C2780007613 @default.
• W2083101071 hasConcept C38485361 @default.
• W2083101071 hasConcept C529278444 @default.
• W2083101071 hasConcept C541997718 @default.
• W2083101071 hasConcept C55493867 @default.
• W2083101071 hasConcept C71924100 @default.
• W2083101071 hasConcept C86803240 @default.
• W2083101071 hasConcept C87753298 @default.
• W2083101071 hasConcept C8891405 @default.

• next