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- W2083103236 abstract "Abstract Background Multiple rapid swallows ( MRS ) during esophageal high resolution manometry ( HRM ) assess esophageal neuromuscular integrity by evaluating postdeglutitive inhibition and rebound contraction, but most reports performed only a single MRS sequence. We assessed patterns of MRS reproducibility during clinical HRM in comparison to a normal cohort. Methods Consecutive clinical HRM studies were included if two separate MRS sequences (four to six rapid swallows ≤4 s apart) were successfully performed. C hicago Classification diagnoses were identified; contraction wave abnormalities were additionally recorded. MRS ‐induced inhibition (contraction ≤3 cm during inhibition phase) and rebound contraction was assessed, and findings compared to 18 controls (28.0 ± 0.7 year, 50.0% female). Reproducibility consisted of similar inhibition and contraction responses with both sequences; discordance was segregated into inhibition and contraction phases. Key Results Multiple rapid swallows were successfully performed in 89.3% patients and all controls; 225 subjects (56.2 ± 0.9 year, 62.7% female) met study inclusion criteria. Multiple rapid swallows were reproducible in 76.9% patients and 94.4% controls (inhibition phase: 88.0% vs 94.4%, contraction phase 86.7% vs 100%, respectively, p = ns). A gradient of reproducibility was noted, highest in well‐developed motor disorders (achalasia spectrum, hypermotility disorders, and aperistalsis, 91.7–100%, p = ns compared to controls); and lower in lesser motor disorders (contraction wave abnormalities, esophageal body hypomotility) or normal studies (62.2–70.8%, p < 0.0001 compared to well‐developed motor disorders). Inhibition phase was most discordant in contraction wave abnormalities, while contraction phase was most discordant when studies were designated normal. Conclusions & Inferences Multiple rapid swallows are highly reproducible, especially in well‐developed motor disorders, and complement the standard wet swallow manometry protocol." @default.
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- W2083103236 date "2014-01-29" @default.
- W2083103236 modified "2023-10-03" @default.
- W2083103236 title "Reproducibility patterns of multiple rapid swallows during high resolution esophageal manometry provide insights into esophageal pathophysiology" @default.
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- W2083103236 doi "https://doi.org/10.1111/nmo.12310" @default.
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