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- W2083108251 abstract "Mesenchymal stem cells (MSCs) are able to differentiate into many types of cells including chondrocytes. Transforming growth factor β1 (TGF-β1) is very important in the regulation of chondrogenesis. Since cartilage-derived morphogenetic protein-1 (CDMP-1) belongs to the TGF-β superfamily, we tested whether CDMP-1 plays any role in the regulation of the differentiation of MSCs into chondrocytes using a high density pellet culture system. Based on the histological staining of glycosaminoglycan using toluidine blue dye-binding method we found that CDMP-1 could initiate chondrogenic differentiation of MSCs as did TGF-β1. However, CDMP-1 was less stimulatory than TGF-β1. The combination of CDMP-1 and TGF-β1 synergically induced chondrogenesis of MSCs. This synergic chondrogenic effect of CDMP-1 together with TGF-β1 was further confirmed by quantification of GAG using dimethylmethylene blue dye-binding assay and immunohistochemical analysis of the expression of cartilage-specific protein collagen II. This study may provide an improved induction approach using MSCs for repairing damaged cartilage." @default.
- W2083108251 created "2016-06-24" @default.
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- W2083108251 date "2004-12-01" @default.
- W2083108251 modified "2023-10-17" @default.
- W2083108251 title "Cartilage-derived morphogenetic protein-1 promotes the differentiation of mesenchymal stem cells into chondrocytes" @default.
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- W2083108251 doi "https://doi.org/10.1016/j.bbrc.2004.10.055" @default.
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