Matches in SemOpenAlex for { <https://semopenalex.org/work/W2083119498> ?p ?o ?g. }
- W2083119498 endingPage "392" @default.
- W2083119498 startingPage "382" @default.
- W2083119498 abstract "Spleen cells from mice selectively bred to produce high affinity antibody responses to protein antigens (HI) had reduced responses to both T and B cell mitogens when compared to those from mice selectively bred to produce low affinity (LO) responses. The reduced response by spleen cells from HI mice was partially reversed by the addition of indomethacin in vitro. Spleen adherent cells from HI mice had increased production of prostaglandin E2 when compared to those from LO mice. In addition, spleen adherent cells from mice which fail to show affinity maturation not only produced lower amounts of PGE2 than those from HI mice but also a decreased proportion of spleen cells adhered to plastic in these mice. To test the possibility that the increased PGE2 production in HI mice was responsible for the production of high affinity antibodies, indomethacin was administered in vivo and resulted in a significant reduction in antibody affinity. The possibility that PGE2 production may control the balance between the TH1 and TH2 cells of Mosmann and Coffman is discussed." @default.
- W2083119498 created "2016-06-24" @default.
- W2083119498 creator A5009182089 @default.
- W2083119498 date "1989-04-01" @default.
- W2083119498 modified "2023-09-27" @default.
- W2083119498 title "Prostaglandin E2 production is enhanced in mice genetically selected to produce high affinity antibody responses" @default.
- W2083119498 cites W1489871342 @default.
- W2083119498 cites W1506916331 @default.
- W2083119498 cites W1511102453 @default.
- W2083119498 cites W1536930695 @default.
- W2083119498 cites W1550160699 @default.
- W2083119498 cites W1559938727 @default.
- W2083119498 cites W1583671290 @default.
- W2083119498 cites W1586056134 @default.
- W2083119498 cites W1591901231 @default.
- W2083119498 cites W1596243988 @default.
- W2083119498 cites W1613104968 @default.
- W2083119498 cites W1655566298 @default.
- W2083119498 cites W1747452239 @default.
- W2083119498 cites W1937944835 @default.
- W2083119498 cites W1966037431 @default.
- W2083119498 cites W1968617992 @default.
- W2083119498 cites W1971661892 @default.
- W2083119498 cites W1978892662 @default.
- W2083119498 cites W1979462654 @default.
- W2083119498 cites W1980041378 @default.
- W2083119498 cites W1991070341 @default.
- W2083119498 cites W1991918785 @default.
- W2083119498 cites W1999609927 @default.
- W2083119498 cites W2000460952 @default.
- W2083119498 cites W2009527350 @default.
- W2083119498 cites W2012177413 @default.
- W2083119498 cites W2013352873 @default.
- W2083119498 cites W2016296153 @default.
- W2083119498 cites W2017482531 @default.
- W2083119498 cites W2029615284 @default.
- W2083119498 cites W2032381660 @default.
- W2083119498 cites W2037551106 @default.
- W2083119498 cites W2042336005 @default.
- W2083119498 cites W2047223130 @default.
- W2083119498 cites W2054840282 @default.
- W2083119498 cites W2059243021 @default.
- W2083119498 cites W2061169185 @default.
- W2083119498 cites W2069978012 @default.
- W2083119498 cites W2073919765 @default.
- W2083119498 cites W2078289443 @default.
- W2083119498 cites W2080651139 @default.
- W2083119498 cites W2083185383 @default.
- W2083119498 cites W2087027341 @default.
- W2083119498 cites W2123141478 @default.
- W2083119498 cites W2124779570 @default.
- W2083119498 cites W2127866588 @default.
- W2083119498 cites W2127977816 @default.
- W2083119498 cites W2129054656 @default.
- W2083119498 cites W2151129289 @default.
- W2083119498 cites W4321828753 @default.
- W2083119498 doi "https://doi.org/10.1016/0008-8749(89)90252-9" @default.
- W2083119498 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2522824" @default.
- W2083119498 hasPublicationYear "1989" @default.
- W2083119498 type Work @default.
- W2083119498 sameAs 2083119498 @default.
- W2083119498 citedByCount "8" @default.
- W2083119498 countsByYear W20831194982016 @default.
- W2083119498 crossrefType "journal-article" @default.
- W2083119498 hasAuthorship W2083119498A5009182089 @default.
- W2083119498 hasConcept C126322002 @default.
- W2083119498 hasConcept C134018914 @default.
- W2083119498 hasConcept C150903083 @default.
- W2083119498 hasConcept C153911025 @default.
- W2083119498 hasConcept C159654299 @default.
- W2083119498 hasConcept C202751555 @default.
- W2083119498 hasConcept C203014093 @default.
- W2083119498 hasConcept C207001950 @default.
- W2083119498 hasConcept C2777956040 @default.
- W2083119498 hasConcept C2780931953 @default.
- W2083119498 hasConcept C55493867 @default.
- W2083119498 hasConcept C71924100 @default.
- W2083119498 hasConcept C86803240 @default.
- W2083119498 hasConceptScore W2083119498C126322002 @default.
- W2083119498 hasConceptScore W2083119498C134018914 @default.
- W2083119498 hasConceptScore W2083119498C150903083 @default.
- W2083119498 hasConceptScore W2083119498C153911025 @default.
- W2083119498 hasConceptScore W2083119498C159654299 @default.
- W2083119498 hasConceptScore W2083119498C202751555 @default.
- W2083119498 hasConceptScore W2083119498C203014093 @default.
- W2083119498 hasConceptScore W2083119498C207001950 @default.
- W2083119498 hasConceptScore W2083119498C2777956040 @default.
- W2083119498 hasConceptScore W2083119498C2780931953 @default.
- W2083119498 hasConceptScore W2083119498C55493867 @default.
- W2083119498 hasConceptScore W2083119498C71924100 @default.
- W2083119498 hasConceptScore W2083119498C86803240 @default.
- W2083119498 hasIssue "2" @default.
- W2083119498 hasLocation W20831194981 @default.
- W2083119498 hasLocation W20831194982 @default.
- W2083119498 hasOpenAccess W2083119498 @default.
- W2083119498 hasPrimaryLocation W20831194981 @default.
- W2083119498 hasRelatedWork W1856085589 @default.
- W2083119498 hasRelatedWork W1933273068 @default.