Matches in SemOpenAlex for { <https://semopenalex.org/work/W2083130009> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W2083130009 endingPage "1103" @default.
- W2083130009 startingPage "1097" @default.
- W2083130009 abstract "Indomethacin antagonizes the natriuretic and chloruretic response to hydrochlorothiazide in most studies. Neither the mechanism nor nephron site of this antagonism has been determined. To identify sites and potential mechanisms, cortical micropuncture was performed during hydrochlorothiazide treatment in control and indomethacin rats. Indomethacin reduced (P less than 0.005) FeCl from 5.20 +/- 0.49% to 2.26 +/- 0.49% (mean +/- SE). MAP, CIn, and plasma volume were not different between groups. SNGFR and fractional proximal fluid and chloride delivery were not different between groups. Fractional chloride delivery to early distal tubules was 10.8 +/- 0.4% in control but 6.2 +/- 0.3% in indomethacin rats (P less than 0.001). Calculated loop chloride reabsorption was greater in indomethacin than control rats during hydrochlorothiazide administration (41.0 +/- 1.6% vs. 34.3 +/- 2.3%; P less than 0.05). Fractional chloride delivery to late distal tubules was 7.8 +/- 0.7% in control and 4.6 +/- 0.3% in indomethacin rats (P less than 0.005), but distal tubule chloride reabsorption was not different between groups. Papillary tissue chloride was less in control than indomethacin rats during hydrochlorothiazide (P less than 0.05). Urinary PGE2 excretion was reduced (P less than 0.001) by indomethacin during hydrochlorothiazide. Thus indomethacin induced reductions in hydrochlorothiazide response result in part from increased chloride reabsorption in the loop segment. This suggests indomethacin antagonizes hydrochlorothiazide by reducing chloride delivery to hydrochlorothiazide's site of action in the distal tubule rather than by effects of indomethacin on hydrochlorothiazide pharmacokinetics." @default.
- W2083130009 created "2016-06-24" @default.
- W2083130009 creator A5005548865 @default.
- W2083130009 creator A5030549999 @default.
- W2083130009 creator A5074221017 @default.
- W2083130009 creator A5076013794 @default.
- W2083130009 creator A5076310025 @default.
- W2083130009 date "1987-05-01" @default.
- W2083130009 modified "2023-09-28" @default.
- W2083130009 title "Mechanism of attenuated hydrochlorothiazide response during indomethacin administration" @default.
- W2083130009 cites W1993395283 @default.
- W2083130009 cites W2016036756 @default.
- W2083130009 cites W2053950451 @default.
- W2083130009 cites W2056154986 @default.
- W2083130009 cites W2059811737 @default.
- W2083130009 cites W2062815836 @default.
- W2083130009 cites W2079981846 @default.
- W2083130009 cites W2090461338 @default.
- W2083130009 cites W2117594247 @default.
- W2083130009 cites W2118262335 @default.
- W2083130009 cites W2139589568 @default.
- W2083130009 cites W2171772418 @default.
- W2083130009 cites W2188551092 @default.
- W2083130009 cites W2322134121 @default.
- W2083130009 cites W2403464624 @default.
- W2083130009 cites W2415332848 @default.
- W2083130009 cites W2417112507 @default.
- W2083130009 cites W2418306979 @default.
- W2083130009 cites W83931581 @default.
- W2083130009 doi "https://doi.org/10.1038/ki.1987.114" @default.
- W2083130009 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3599650" @default.
- W2083130009 hasPublicationYear "1987" @default.
- W2083130009 type Work @default.
- W2083130009 sameAs 2083130009 @default.
- W2083130009 citedByCount "18" @default.
- W2083130009 countsByYear W20831300092015 @default.
- W2083130009 countsByYear W20831300092019 @default.
- W2083130009 crossrefType "journal-article" @default.
- W2083130009 hasAuthorship W2083130009A5005548865 @default.
- W2083130009 hasAuthorship W2083130009A5030549999 @default.
- W2083130009 hasAuthorship W2083130009A5074221017 @default.
- W2083130009 hasAuthorship W2083130009A5076013794 @default.
- W2083130009 hasAuthorship W2083130009A5076310025 @default.
- W2083130009 hasBestOaLocation W20831300091 @default.
- W2083130009 hasConcept C126322002 @default.
- W2083130009 hasConcept C134018914 @default.
- W2083130009 hasConcept C178790620 @default.
- W2083130009 hasConcept C185592680 @default.
- W2083130009 hasConcept C2778695967 @default.
- W2083130009 hasConcept C2779918671 @default.
- W2083130009 hasConcept C2780091579 @default.
- W2083130009 hasConcept C2780361556 @default.
- W2083130009 hasConcept C2781231759 @default.
- W2083130009 hasConcept C56906281 @default.
- W2083130009 hasConcept C71924100 @default.
- W2083130009 hasConcept C84393581 @default.
- W2083130009 hasConcept C98274493 @default.
- W2083130009 hasConceptScore W2083130009C126322002 @default.
- W2083130009 hasConceptScore W2083130009C134018914 @default.
- W2083130009 hasConceptScore W2083130009C178790620 @default.
- W2083130009 hasConceptScore W2083130009C185592680 @default.
- W2083130009 hasConceptScore W2083130009C2778695967 @default.
- W2083130009 hasConceptScore W2083130009C2779918671 @default.
- W2083130009 hasConceptScore W2083130009C2780091579 @default.
- W2083130009 hasConceptScore W2083130009C2780361556 @default.
- W2083130009 hasConceptScore W2083130009C2781231759 @default.
- W2083130009 hasConceptScore W2083130009C56906281 @default.
- W2083130009 hasConceptScore W2083130009C71924100 @default.
- W2083130009 hasConceptScore W2083130009C84393581 @default.
- W2083130009 hasConceptScore W2083130009C98274493 @default.
- W2083130009 hasIssue "5" @default.
- W2083130009 hasLocation W20831300091 @default.
- W2083130009 hasLocation W20831300092 @default.
- W2083130009 hasOpenAccess W2083130009 @default.
- W2083130009 hasPrimaryLocation W20831300091 @default.
- W2083130009 hasRelatedWork W1024594680 @default.
- W2083130009 hasRelatedWork W1924012380 @default.
- W2083130009 hasRelatedWork W1984193137 @default.
- W2083130009 hasRelatedWork W1995753918 @default.
- W2083130009 hasRelatedWork W2001915541 @default.
- W2083130009 hasRelatedWork W2014673722 @default.
- W2083130009 hasRelatedWork W2072980676 @default.
- W2083130009 hasRelatedWork W2082456910 @default.
- W2083130009 hasRelatedWork W2083130009 @default.
- W2083130009 hasRelatedWork W2399285905 @default.
- W2083130009 hasVolume "31" @default.
- W2083130009 isParatext "false" @default.
- W2083130009 isRetracted "false" @default.
- W2083130009 magId "2083130009" @default.
- W2083130009 workType "article" @default.