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• W2083133044 endingPage "567" @default.
• W2083133044 startingPage "561" @default.
• W2083133044 abstract "The complement system protects the host against invading organisms, initiates inflammation and dispose of immune complexes and the products of inflammatory injury. The complement system provides an important link between the innate and adaptive immune systems. Experimental observations suggest that increased complement activation causes and/or perpetuates inflammation during pregnancy. Recent studies suggest a link between complement activation and preeclampsia. Excessive activation or insufficient regulation of complement recruits leukocytes and unleashes potent inflammatory and anti-angiogenic mediators associated with placental insufficiency and maternal endothelial dysfunction characteristic of preeclampsia. We review the animal and human studies that link complement activation and pathogenic events in preeclampsia, present evidence that activation of the complement system is associated with the development of preeclampsia and provides new targets to prevent its complications." @default.
• W2083133044 created "2016-06-24" @default.
• W2083133044 creator A5070689104 @default.
• W2083133044 creator A5090344796 @default.
• W2083133044 date "2010-07-01" @default.
• W2083133044 modified "2023-10-12" @default.
• W2083133044 title "Dysregulated Complement Activation as a Common Pathway of Injury in Preeclampsia and Other Pregnancy Complications" @default.
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