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- W2083133945 abstract "With the recent rapid increase in scientific understanding of the human genome it is becoming possible to identify the extent to which genetic variations influence drug response. The emergence of pharmacogenetics heralds a new era in which drug therapies will be selected on the basis of differences in individuals’ genotypes, enhancing drug safety and efficacy. The major focus of this review is pharmacogenetics of antihypertensive drugs. Genetics can influence the pharmacokinetics and pharmacodynamics of such drugs at different levels. The presently available applications of genetic concepts to some drugs commonly used in the treatment of hypertension (ACE-inhibitors, diuretics, beta-blockers …) will be summarized. Also sensitivity to salt intake will be considered as an example of pharmacogenetics. The identification of genetic markers of drug response will help to achieve a better control of blood pressure in the population, by allowing a better tailor of antihypertensive therapy to individual patients." @default.
- W2083133945 created "2016-06-24" @default.
- W2083133945 creator A5035489654 @default.
- W2083133945 creator A5061373096 @default.
- W2083133945 creator A5086351953 @default.
- W2083133945 date "2004-04-01" @default.
- W2083133945 modified "2023-10-17" @default.
- W2083133945 title "Trends in pharmacogenomics of drugs acting on hypertension" @default.
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- W2083133945 doi "https://doi.org/10.1016/j.phrs.2003.07.018" @default.
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