FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2083137415> ?p ?o ?g. }

• W2083137415 endingPage "983" @default.
• W2083137415 startingPage "973" @default.
• W2083137415 abstract "Vulvar squamous cell carcinoma (SCC) affects a spectrum of women with granulomatous vulvar diseases, human papillomavirus (HPV) infections, and chronic inflammatory vulvar dermatoses. To determine whether there is evidence of chromosomal instability occurring in synchronous skin surrounding vulvar SCCs, we investigated abnormalities in chromosome 17 copy number. Samples of SCC, vulvar intraepithelial neoplasia (VIN), and surrounding vulvar skin were obtained from all vulvar excisions performed for squamous neoplasia at Albany Medical College from 1996 to 1997. Histological categorization, fluorescent in situ hybridization (FISH) for the alpha satellite region of chromosome 17, DNA content by image analysis, and Ki-67 labeling were evaluated. Controls of normal vulvar skin not associated with cancer were used for comparison. One hundred ten specimens were obtained from 33 patients with either SCC or VIN 3 and consisted of 49 neoplastic, 52 nonneoplastic, and 9 histologically normal vulvar skin samples. The majority of SCCs (88%) and a minority (18%) of VIN 3 excisions were associated with lichen sclerosus. Normal vulvar skin controls did not exhibit chromosome 17 polysomy (cells with more than four FISH signals), whereas 56% of normal vulvar skin associated with cancer did. Moreover, the frequency of polysomy significantly increased as the histological classification progressed from normal to inflammatory to neoplastic lesions. The largest mean value and variance for chromosome 17 copy number was identified in SCCs (2.4 +/- 1.0) with intermediate values identified, in decreasing order, for SCC in situ (2.1 +/- 1.0), VIN 2 (2.1 +/- 0.8), lichen sclerosus (2.0 +/- 0.5), lichen simplex chronicus (1.9 +/- 0.4), and normal skin associated with SCC (1.8 +/- 0.4) compared with control vulvar skin (1.5 +/- 0. 05). Concordance of chromosome 17 aneusomy between cancers and synchronous skin lesions was found in 48% of patients. Loss of chromosome 17 was identified 5% of all samples and was significantly associated with women with SCC in situ (HPV-related). Both DNA content and Ki-67 labeling positively and significantly correlated with mean chromosome 17 copy number (r = 0.1, P: = 0.007). A high degree of genetic instability (aneuploidy) occurs in the skin surrounding vulvar carcinomas. As these events could be detected in histologically normal skin and inflammatory lesions (lichen sclerosus), chromosomal abnormalities may be a driving force in the early stages of carcinogenesis. Differences in chromosomal patterns (loss or gain) support the concept of at least two pathways in vulvar carcinogenesis." @default.
• W2083137415 created "2016-06-24" @default.
• W2083137415 creator A5031871324 @default.
• W2083137415 creator A5034539392 @default.
• W2083137415 creator A5049483972 @default.
• W2083137415 creator A5063971464 @default.
• W2083137415 creator A5072401496 @default.
• W2083137415 creator A5079656446 @default.
• W2083137415 creator A5088559019 @default.
• W2083137415 date "2000-09-01" @default.
• W2083137415 modified "2023-09-25" @default.
• W2083137415 title "Chromosome 17 Aneusomy Detected by Fluorescence in Situ Hybridization in Vulvar Squamous Cell Carcinomas and Synchronous Vulvar Skin" @default.
• W2083137415 cites W130569595 @default.
• W2083137415 cites W145810641 @default.
• W2083137415 cites W1514293516 @default.
• W2083137415 cites W1515905084 @default.
• W2083137415 cites W1533555842 @default.
• W2083137415 cites W1544851750 @default.
• W2083137415 cites W1548557633 @default.
• W2083137415 cites W1556962520 @default.
• W2083137415 cites W15744948 @default.
• W2083137415 cites W1612859 @default.
• W2083137415 cites W1889355034 @default.
• W2083137415 cites W1964359203 @default.
• W2083137415 cites W1971794557 @default.
• W2083137415 cites W1981080992 @default.
• W2083137415 cites W1982291282 @default.
• W2083137415 cites W1983015945 @default.
• W2083137415 cites W1983486268 @default.
• W2083137415 cites W1984188658 @default.
• W2083137415 cites W1991949008 @default.
• W2083137415 cites W1992263763 @default.
• W2083137415 cites W1993406721 @default.
• W2083137415 cites W1996293570 @default.
• W2083137415 cites W1998025524 @default.
• W2083137415 cites W1999170381 @default.
• W2083137415 cites W1999597014 @default.
• W2083137415 cites W2001258296 @default.
• W2083137415 cites W2010161030 @default.
• W2083137415 cites W2017288760 @default.
• W2083137415 cites W2023228900 @default.
• W2083137415 cites W2025728444 @default.
• W2083137415 cites W2033179836 @default.
• W2083137415 cites W2033742495 @default.
• W2083137415 cites W2033949742 @default.
• W2083137415 cites W2048585324 @default.
• W2083137415 cites W2050506084 @default.
• W2083137415 cites W2072793255 @default.
• W2083137415 cites W2073387947 @default.
• W2083137415 cites W2080308138 @default.
• W2083137415 cites W2085429487 @default.
• W2083137415 cites W2087231331 @default.
• W2083137415 cites W2087624113 @default.
• W2083137415 cites W2089495575 @default.
• W2083137415 cites W2091510334 @default.
• W2083137415 cites W2093790645 @default.
• W2083137415 cites W2115148646 @default.
• W2083137415 cites W2123820544 @default.
• W2083137415 cites W2125623796 @default.
• W2083137415 cites W2143157552 @default.
• W2083137415 cites W2149157760 @default.
• W2083137415 cites W2152195666 @default.
• W2083137415 cites W2157418947 @default.
• W2083137415 cites W2159568631 @default.
• W2083137415 cites W2163894688 @default.
• W2083137415 cites W2167118789 @default.
• W2083137415 cites W2239437941 @default.
• W2083137415 cites W227331670 @default.
• W2083137415 cites W2318593146 @default.
• W2083137415 cites W2318985206 @default.
• W2083137415 cites W2401192132 @default.
• W2083137415 cites W2411383118 @default.
• W2083137415 cites W2411708311 @default.
• W2083137415 cites W2413727809 @default.
• W2083137415 cites W2417547070 @default.
• W2083137415 cites W2424317448 @default.
• W2083137415 cites W2463848000 @default.
• W2083137415 cites W436120300 @default.
• W2083137415 doi "https://doi.org/10.1016/s0002-9440(10)64610-x" @default.
• W2083137415 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1885895" @default.
• W2083137415 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10980136" @default.
• W2083137415 hasPublicationYear "2000" @default.
• W2083137415 type Work @default.
• W2083137415 sameAs 2083137415 @default.
• W2083137415 citedByCount "23" @default.
• W2083137415 countsByYear W20831374152012 @default.
• W2083137415 countsByYear W20831374152015 @default.
• W2083137415 countsByYear W20831374152017 @default.
• W2083137415 countsByYear W20831374152019 @default.
• W2083137415 countsByYear W20831374152022 @default.
• W2083137415 crossrefType "journal-article" @default.
• W2083137415 hasAuthorship W2083137415A5031871324 @default.
• W2083137415 hasAuthorship W2083137415A5034539392 @default.
• W2083137415 hasAuthorship W2083137415A5049483972 @default.
• W2083137415 hasAuthorship W2083137415A5063971464 @default.
• W2083137415 hasAuthorship W2083137415A5072401496 @default.
• W2083137415 hasAuthorship W2083137415A5079656446 @default.
• W2083137415 hasAuthorship W2083137415A5088559019 @default.

• next