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- W2083139211 abstract "Abstract The inhibitory effect of guanidine on the multiplication of poliovirus in HeLa cells is suppressed by the amino acids methionine, leucine, and valine but also by choline. Of substances structurally similar to choline, dimethylethanolamine and dimethylpropanolamine are much more effective and ethanolamine is also more effective than choline. A synergistic effect between choline derivatives and amino acids could be demonstrated. Cells of different origin differed in response to various guanidine competitors. Guanidine inhibition was reversed most effectively by choline in KB cells and by dimethylethanolamine in HeLa cells, but cynomolgus monkey kidney cells gave only partial reversion with these metabolites. The reversion of guanidine inhibition was, however, not affected by actinomycin or folic acid analogs. The guanidine competitors could neither affect the yield nor replace guanidine for guanidine-dependent variants of the virus in HeLa cells. A low molecular weight compound was demonstrated in poliovirus-infected cells but not in uninfected cells that were labeled with choline-C 14 H 3 . The implications of these findings on the mechanism of guanidine inhibition are discussed." @default.
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- W2083139211 date "1966-06-01" @default.
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- W2083139211 title "The reversion of guanidine inhibition of poliovirus synthesis" @default.
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- W2083139211 doi "https://doi.org/10.1016/0042-6822(66)90039-0" @default.
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