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- W2083143886 abstract "All secretory pituitary cells exhibit spontaneous and extracellular Ca2+-dependent electrical activity. Somatotrophs and lactotrophs fire plateau-bursting action potentials, which generate Ca2+ signals of sufficient amplitude to trigger hormone release. Gonadotrophs also fire action potentials spontaneously, but as single, high-amplitude spikes with limited ability to promote Ca2+ influx and secretion. However, Ca2+ mobilization in gonadotrophs transforms single spiking into plateau-bursting-type electrical activity and triggers secretion. Patch clamp analysis revealed that somatotrophs and lactotrophs, but not gonadotrophs, express BK (big)-type Ca2+-controlled K+ channels, activation of which is closely associated with voltage-gated Ca2+ influx. Conversely, pituitary gonadotrophs express SK (small)-type Ca2+-activated K+ channels that are colocalized with intracellular Ca2+ release sites. Activation of both channels is crucial for plateau-bursting-type rhythmic electrical activity and secretion." @default.
- W2083143886 created "2016-06-24" @default.
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- W2083143886 date "2005-05-01" @default.
- W2083143886 modified "2023-10-16" @default.
- W2083143886 title "Biophysical basis of pituitary cell type-specific Ca2+ signaling–secretion coupling" @default.
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- W2083143886 doi "https://doi.org/10.1016/j.tem.2005.03.003" @default.
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