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• W2083146180 startingPage "1132" @default.
• W2083146180 abstract "Research suggests an association between abnormal exocytosis and schizophrenia. We previously demonstrated increased synaptosomal associated protein, 25 kDa (SNAP-25), a member of the exocytotic mechanism, in the cerebrospinal fluid (CSF) of schizophrenia subjects. In this study, we explored SNAP-25 level and clinical variables in a new group of subjects.Twenty-five haloperidol-treated subjects with chronic schizophrenia and twenty-five healthy control subjects participated in the study. Subjects received haloperidol treatment for at least 3 months and then had a lumbar puncture (n = 19). Medication was replaced by placebo, and the lumbar puncture was repeated (n = 25) after 6 weeks or sooner if limited psychotic symptoms occurred. We measured the level of SNAP-25 in the CSF and symptoms with the Brief Psychiatric Rating Scale (BPRS).In both haloperidol (p =.001) and placebo (p =.001) treatment conditions, SNAP-25 was elevated. There was no significant difference in SNAP-25 level between conditions. We identified significant positive correlations among SNAP-25 and the BPRS total score and psychosis and thinking disturbance subscales in subjects on haloperidol.These observations confirm our previous report of elevated CSF SNAP-25 and suggest that synaptic pathology may be linked with the pathophysiology of schizophrenia." @default.
• W2083146180 created "2016-06-24" @default.
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• W2083146180 date "2003-06-01" @default.
• W2083146180 modified "2023-10-17" @default.
• W2083146180 title "Elevated cerebrospinal fluid SNAP-25 in schizophrenia" @default.
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• W2083146180 doi "https://doi.org/10.1016/s0006-3223(02)01599-8" @default.
• W2083146180 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12814864" @default.
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